The DDAH/ADMA/NOS pathway

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Presentation transcript:

The DDAH/ADMA/NOS pathway Cam T.L Tran, James M Leiper, Patrick Vallance  Atherosclerosis Supplements  Volume 4, Issue 4, Pages 33-40 (December 2003) DOI: 10.1016/S1567-5688(03)00032-1

Fig. 1 Structure of l-arginine and endogenous methylarginines l-NMMA, ADMA and SDMA. Only l-NMMA and ADMA are nitric oxide synthase inhibitors. Atherosclerosis Supplements 2003 4, 33-40DOI: (10.1016/S1567-5688(03)00032-1)

Fig. 2 Proposed mechanism for regulation of nitric oxide production by DDAH, suggested initially by [28]. Atherosclerosis Supplements 2003 4, 33-40DOI: (10.1016/S1567-5688(03)00032-1)

Fig. 3 Chromosomal localization of human DDAH1 and DDAH2 genes. Atherosclerosis Supplements 2003 4, 33-40DOI: (10.1016/S1567-5688(03)00032-1)