Acid-suppressive medications during pregnancy and risk of asthma and allergy in children: A systematic review and meta-analysis Rebecca E. Devine, MPH,

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Presentation transcript:

Acid-suppressive medications during pregnancy and risk of asthma and allergy in children: A systematic review and meta-analysis Rebecca E. Devine, MPH, Nicola McCleary, PhD, Aziz Sheikh, MD, Bright I. Nwaru, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 6, Pages 1985-1988.e12 (June 2017) DOI: 10.1016/j.jaci.2016.09.046 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Meta-analysis of studies investigating the association between maternal use of any acid-suppressive medication (ASM) during pregnancy and the risk of asthma in the offspring. RR represents the risk ratio of association. A, Estimates by study design. B, Estimates by study design, excluding Yitshak-Sade 2016. Population represents the number of participants recruited into the study. H2RA, H2-receptor antagonists; PPI, proton pump inhibitors. Journal of Allergy and Clinical Immunology 2017 139, 1985-1988.e12DOI: (10.1016/j.jaci.2016.09.046) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A and B, Meta-analysis of studies investigating the association between maternal use of H2-receptor antagonists (H2RA) and proton pump inhibitors (PPI) during pregnancy and the risk of asthma in the offspring. HR represents the hazard ratio of association. Population represents the number of participants recruited into the study. Journal of Allergy and Clinical Immunology 2017 139, 1985-1988.e12DOI: (10.1016/j.jaci.2016.09.046) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram for database search of studies investigating the association between maternal use of acid-suppressive medications during pregnancy and risk of asthma and allergy in the offspring. Journal of Allergy and Clinical Immunology 2017 139, 1985-1988.e12DOI: (10.1016/j.jaci.2016.09.046) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions