LMNA -mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy Sui Tingting 1 ;Liu Di 1 ;Liu Tingjun 1 ;Deng.

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LMNA -mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy Sui Tingting 1 ;Liu Di 1 ;Liu Tingjun 1 ;Deng Jichao 1 ;Chen Mao 1 ;Xu Yuanyuan 1 ;Song Yuning 1 ;Ouyang Hongsheng 1 ;Lai Liangxue 1, 2 ;Li Zhanjun 1 ; 1 Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun 130062, China ; 2 Key Laboratory of Regenerative Biology, and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China ; Figure 3. Cardiomyopathy of LMNA -KO rabbits. A The heart from 18-day-old LMNA -KO rabbits and WT control. B The increased left ventricular diastolic diameter in LMNA -KO rabbits. C The decreased left ventricular ejection fraction EF in LMNA -KO rabbits. D The decreased fractional shortening in LMNA -KO rabbits. E The decreased heart rate in LMNA -KO rabbits. Data were presented as means #cod#x000B1; SEM of at least three rabbits per group and analyzed by Student#cod#x02019;s t -tests using GraphPad Prism software 7.0. #cod#x0002A; p #cod#x0003C; 0.05; #cod#x0002A;#cod#x0002A; p #cod#x0003C; 0.01; #cod#x0002A;#cod#x0002A;#cod#x0002A; p #cod#x0003C; 0.001. Normalized LVDD, LV diastolic diameter-to-body weight ratio. F H#cod#x00026;E-staining and Masson#cod#x02019; trichrome-staining of cardiac muscles from WT and LMNA- KO rabbits, showing significant fibrosis Red arrows and cardiomyocytes loss Blue arrows in LMNA -KO rabbits. G H#cod#x00026;E-staining and Oil red-staining of the cardiac muscles from WT and LMNA- KO rabbits, showing significant fat infiltration Green arrows in LMNA -KO rabbits. H Aorta tissues of the 18-day-old LMNA -KO rabbits and WT controls. I H#cod#x00026;E-staining of the aorta from WT and LMNA -KO rabbits. Scale bar, 50 #cod#x003BC;m. null,null,0(0),null-null. Doi:10.14336/AD.2018.0209