Nanoparticle Chemical Sensors for UUXO Detection Christian Schoen, PhD VP CTO Concurrent Analytical Inc. Partnership Workshop: Robotic Technology To Support.

Slides:



Advertisements
Similar presentations
Revolutionary Technology in pH Measurement
Advertisements

The Concentration of Substances
Outline Curriculum (5 lectures) Each lecture  45 minutes
Chapter 12 - Immunological methods
Tunable Surface Assembly of Gold Nanorods for Biosensor Applications
Chemical Sensors for Autonomous and Lagrangian Platforms Ken Johnson, Monterey Bay Aquarium Research Institute.
Who Wants To Be A Millionaire?
SAE J1772™ Gery J. Kissel Engineering Specialist General Motors
High Throughput Donor Plasma NAT Screening Assay Applied to Acute HIV Detection in a Public Health Setting December 5, 2007 Josh Goldsmith, Ph.D. National.
Capability of Immobilisation techniques and detection of Ab-Ag interactions by Eyad Hamad November 2010.
Surface Plasmon Resonance Biosensors
T. Ozaki, K. Sugano, T. Tsuchiya, O. Tabata
Gold Nanorod Biosensors and Single Particle Spectroscopy Jason H. Hafner MURI site visit July 27, 2005.
A New and Better Forensic Test for Independent Forensics
Base 10 and Powers of 10.
Introduction from the “Front End” 30 Years of Archiving MMS Marine Invertebrates at the Smithsonian National Museum of Natural History First: Why does.
Cocona Competitive Landscape A comparison of Cocona fabrics against other fabrics.
Immune Testing.
University of Missouri DETECTION AND SURVEILLANCE Sheila Grant Department of Biological Engineering UMC.
Nanobiosensors Sara Huefner November 6, Outline Biosensor Background –What is a Biosensor? –Components of a Biosensor –Principles of Detection Biosensors.
Nanomaterial’s Application in Biotechnology Lei Sun Project manager Digital Health Group Intel Corp.
Design of Health Technologies lecture 12 John Canny 10/17/05.
Introduction to Immunoassays
Enzyme-linked Immunosorbent Assay
NanoDLSay TM – A New Solution for Biomolecular Detection and Analysis February 2010 Copyright of Nano Discovery, Inc.
Concentrations and Consumer Products. Percentage Volume/Volume (% v/v) Commonly used when both the solute and the solvent are liquids volume/volume =
Volumetric analysis Chemistry 321, Summer Volumetric analysis involves titrations A titration is the use of a known concentration reagent to determine.
Altogen Labs, 4020 S Industrial Dr, Suite 130, Austin TX 78744, USA  ELIS A Enzyme-Linked Immunosorbent Assay ELISA.
EXAMPLE 4 Find perimeters of similar figures Swimming A town is building a new swimming pool. An Olympic pool is rectangular with length 50 meters and.
NeSSI Compatible Spectroscopic Flow Cells
(Enzyme Linked Immunosorbent Assay)
 Nano Discovery Inc. Copyright Nano Discovery Inc. NANO.
Development of high-density photonic sensor chips Robert Magnusson Electrical & Computer Engineering University of Connecticut and Resonant Sensors Incorporated.
Long-range impact: Arrays of microheater sensors containing individual “catalyst pixels”, each optimized for a particular target gas, are envisioned. These.
Quiz 1 The questions will be displayed for a few minutes on the screen Write your answers on piece of paper with your name & student number at the top.
C L E A R A N T TM Limiting Batch Size: Effects of Batch Size on Risk of Contamination with Infectious Agents Thomas J. Lynch, J.D., Ph.D. Senior Vice.
Concentrations. Part Per Hundred Represented by the percent (%) symbol 1 part per 100 parts 1 part in 10 2 A value of 1 × Equivalent to about 15.
University of Virginia Gabriel Laufer University of Virginia, Mechanical and Aerospace Engineering, Charlottesville, VA Passive Stand-Off Detection.
NanoDLSay TM – A Powerful Tool for Nanoparticle, Nanomedicine, Biomolecular and Pharmaceutical Research February 2010 Copyright.
Biosensor Development Aptasensor for a small organic molecule, TCA Peter Pfeiffer Bioengineering and Bioelectrochemistry Group University Rovira i Virgili.
School of Biomedical Engineering, Science & Health Systems V 1.0 SD [020214] The sensor market is one of the fastest.
6.1.1 RATIOS, PROPORTIONS, AND THE GEOMETRIC MEAN Chapter 6: Similarity.
Fighting Cancer with Gold Nanoshells.
Nanotechnology The concept of nanotechnology is defined as an art handling of tiny particles (1nm= m). The structures have different properties.
Water toxicity detection through perfusion and monitoring of living cells on a microfluidic chip Fang Li, Ph.D. Department of Mechanical Engineering New.
NANOPARTICLES Their application in probing Glass Transition Temperature of Polymers. By RATAN KISHORE PUTLA Mechanical & Aerospace Engineering Oklahoma.
Spring Celebration Donald Lucas, Ph.D. Profs. Cathy Koshland (PI), Lydia Sohn, Peidong Yang, and John Arnold Nanotechnology-Based Environmental.
Biochemical instrumental analysis - 12 Dr. Maha Al-Sedik 2015 CLS 332.
DISCONTINUATION OR NO DISCONTIUNATION: COMPARISON OF SINGLE UNIT HIV ANTIGEN TESTING VS. POOLED NAT TESTING Gerald Schochetman, Ph.D. Abbott Laboratories.
NanoDLSayTM – A Powerful Tool for Nanoparticle, Nanomedicine, Biomolecular and Pharmaceutical Research Nano Discovery, Inc February 2010 Copyright of.
Lab-on-a-Chip The Ideal Technology for Bio-chemical Analysis
Microfluidic Raman Spectrometer Biosensor By: Raiders of the Lost Pathogens Sharlee Mahoney and Nathan Fletcher 1.
Telephone    Provider of Global Contract Research Services Accelerating Preclinical Research, Drug Discovery.
© 2008 D3 Technologies Ltd. All rights reserved. Private and Confidential. D3 Technologies – SERS products / solutions / services.
Gold Nanorods- used in cancer detection Carbon Nanotubes- used in bullet proofing Graphene Devices- used for sensing Hazardous Substances.
ELISA BASICS.
Sharlee Mahoney Dept of Chemical and Petroleum Engineering Dr. Patrick Johnson.
CONTENTS INTRODUCTION COMPONENTS OF BIOSENSORS NANOBIOSENSORS TYPES OF NANOSENSORS AND THEIR APPLICATIONS ENVIRONMENTAL APPLICATIONS FUTURE APPLICATION.
GOLD NANOPARTICLES: A POSSIBLE CURE FOR PANCREATIC CANCER
Gene Therapy and Viral Vectors
A Low Power Carbon Nanotube Chemical Sensor System
ELISA.
Agglutination test It is one of important laboratory method to detect antigen antibody reaction. It provides flexible and useful method for semi quantitating.
What are we doing Today? Review Day Homework Questions Review
Proteon Scientists from Creative Biolabs are willing to provide custom antibody affinity measurement using ProteOn system. The system is a surface plasmon.
Flight Across the Atlantic
Carbon Nanotube Biosensors with Aptamers as Molecular Recognition Elements Jeong-O Lee Fusion-Biotechnology Research Center, Korea Research Institute of.
Controlling Sensors Efficiently with MCUs
Topic 1: Be able to combine functions and determine the resulting function. Topic 2: Be able to find the product of functions and determine the resulting.
Gold Nanoparticles Gold nanoparticles are one type of metallic nanoparticle; others are Ni, and TiO2 nanoparticles. It has advantages over other metal.
Presentation transcript:

Nanoparticle Chemical Sensors for UUXO Detection Christian Schoen, PhD VP CTO Concurrent Analytical Inc. Partnership Workshop: Robotic Technology To Support Underwater Unexploded Ordnance (UUXO) Ops Friday, 10 Oct Hilton Hawaiian Village, Waikiki

CEROS Funded Effort In conjunction with Sea Engineering, funded by CEROS to develop UUXO detection systems Kahoolawe coast

Define Goals Analyzed seawater off Kahoolawe Proximal to leaky explosive – Was able to measure 40 ppm close, 1 5 meters – meters? Chemical radiation from explosives does not occur in a hemispherical pattern UUXO plume

How sensitive is this? Sharks detect blood in seawater at 100 ppmillion 1 ppm = 1 drop in 50 liters

Comparison One part per trillion (1 ppt) is a proportion equivalent to one drop of water diluted into twenty olympic size swimming pools

Detection System Requirements Extremely sensitive (~ppt) Fast (seconds) Corrosion resistant Biofouling resistant Low power consuming/ remote stand alone operation Directional?

Solution: Optical Transducer Optical transducer based on antibody/antigen mechanisms Optical transducer based on antibody/antigen mechanisms Benefits: Benefits: – Antibody/antigen interaction is very sensitive (used in diagnostic assays at similar sensitivity requirements) – Optical systems can be made to be robust in ocean environments – Optical systems can be made to be remotely operable/low power Disadvantages: Disadvantages: – Not directional – passive system UUXO Optical Transducer

Gold Nanorods Geometrically-tunable plasmon resonance throughout visible/NIR Geometrically-tunable plasmon resonance throughout visible/NIR Highly monodisperse, scalable manufacturing method Highly monodisperse, scalable manufacturing method Potential as multimodal agents for sensors Potential as multimodal agents for sensors Polymer coated gold is extremely robust in corrosive environments Polymer coated gold is extremely robust in corrosive environments

Simple

How Sensitive/Selective? Work to ppt Using Raman labels is 1,000,000x better Can work with multiple target concurrently Problem:

Sprayjet TM Solution

Current SOTA is 30 minutes to 2 days For ppt, sprayjet can work in a few seconds at many ml per sec. How much quicker?

Conclusion Optical Transducers, particularly plasmonic gold nanorods, can be used as a robust sensor for UUXOs