Abd Moain Abu Dabrh, MBBCh, MS, Mark W

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Presentation transcript:

Nonrevascularization-based treatments in patients with severe or critical limb ischemia Abd Moain Abu Dabrh, MBBCh, MS, Mark W. Steffen, MD, MPH, Noor Asi, MD, Chaitanya Undavalli, MBBS, Zhen Wang, PhD, Mohamed B. Elamin, MD, Michael S. Conte, MD, Mohammad Hassan Murad, MD, MPH Journal of Vascular Surgery Volume 62, Issue 5, Pages 1330-1339.e13 (November 2015) DOI: 10.1016/j.jvs.2015.07.069 Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Fig Flowchart shows the selection process of eligible studies. CLI, Critical limb ischemia. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 1 (online only) Meta-analysis of mortality in patients after receiving bone marrow mononuclear cells (BM-MNC). CI, Confidence interval; OR, Odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 2 (online only) Meta-analysis of mortality in patients after receiving bone marrow mononuclear cells (BM-MNC) plus nonviral 1 fibroblast growth factor (NV1FGF) plus hepatocyte growth factor (HGF) (combined effect of biological treatments). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 3 (online only) Meta-analysis of mortality in patients after receiving hepatocyte growth factor (HGF). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 4 (online only) Meta-analysis of mortality outcome in patients after receiving hydroxyethylrutoside plus warfarin. CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 5 (online only) Meta-analysis of mortality in patients after receiving nonviral 1 fibroblast growth factor (NV1FGF). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 6 (online only) Meta-analysis of mortality outcome in patients after receiving intermittent pneumatic compression (IPC). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 7 (online only) Meta-analysis of mortality outcome in patients after receiving prostacyclin. CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 8 (online only) Meta-analysis of mortality in patients after receiving spinal cord stimulator (SCS) implant (1 = without prostaglandin E1 [PGE1], 2 = with PGE1). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 9 (online only) Meta-analysis of patients with improved healing after receiving hepatocyte growth factor (HGF). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 10 (online only) Meta-analysis of patients with improved healing after receiving intermittent pneumatic compression (IPC). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 11 (online only) Meta-analysis of patients with improved healing after receiving prostacyclin. CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 12 (online only) Meta-analysis of patients with improved healing after receiving spinal cord stimulation (SCS) implant. CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 13 (online only) Meta-analysis of patients with limb loss outcome after receiving bone marrow mononuclear cells (BM-MNC). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. 1 = Studies reporting patients with limb loss outcome after receiving BM-MNC. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 14 (online only) Meta-analysis of patients with limb loss in patients after receiving bone marrow mononuclear cells (BM-MNC), hepatocyte growth factor (HGF), and nonviral 1 fibroblast growth factor (NV1FGF) (combined effect of biological treatments). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 15 (online only) Meta-analysis of patients with limb loss outcome after receiving hepatocyte growth factor (HGF). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 16 (online only) Meta-analysis of patients with limb loss outcome after receiving nonviral 1 fibroblast growth factor (NV1FGF). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 17 (online only) Meta-analysis of patients with limb loss outcome after receiving intermittent pneumatic compression (IPC). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 18 (online only) Meta-analysis of patients with limb loss outcome after receiving prostacyclin. CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 19 (online only) Meta-analysis of patients with limb loss outcome after receiving spinal cord stimulator (SCS) implant (1 = without prostaglandin E1 [PGE1], 2 = with PGE1, 3 = with adjunctive medical treatment). CI, Confidence interval; OR, odds ratio. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The solid vertical line indicates no effect. The dashed vertical line indicates the summary measure, with the associated diamond indicating the weighted mean difference and the lateral tips of the diamond indicating the associated CIs. The horizontal lines represent the 95% CIs. Journal of Vascular Surgery 2015 62, 1330-1339.e13DOI: (10.1016/j.jvs.2015.07.069) Copyright © 2015 Society for Vascular Surgery Terms and Conditions