Cardiovascular and cerebrovascular events among patients receiving omalizumab: Results from EXCELS, a prospective cohort study in moderate to severe asthma 

Slides:



Advertisements
Similar presentations
Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,
Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,
Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
D-dimer: A biomarker for antihistamine-resistant chronic urticaria
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Risk of an asthma exacerbation after bariatric surgery in adults
Fatty acids, inflammation, and asthma
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Increased IgE levels are linked to faster relapse in patients with omalizumab- discontinued chronic spontaneous urticaria  Ragip Ertas, MD, Kemal Ozyurt,
Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study
Is 9 more than 2 also in allergic airway inflammation?
Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trial  Marko Kalliomäki, MD, PhD,
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Fatty acids, inflammation, and asthma
Congenital malformations among infants born to women receiving montelukast, inhaled corticosteroids, and other asthma medications  Linda M. Nelsen, MHS,
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
A randomized multicenter study evaluating Xolair persistence of response after long- term therapy  Dennis Ledford, MD, William Busse, MD, Benjamin Trzaskoma,
Test for Respiratory and Asthma Control in Kids (TRACK): A caregiver-completed questionnaire for preschool-aged children  Kevin R. Murphy, MD, Robert.
The Editors’ Choice Journal of Allergy and Clinical Immunology
Cardiovascular and cerebrovascular events among patients receiving omalizumab: Results from EXCELS, a prospective cohort study in moderate to severe asthma 
Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis  George Philip, MD, Janet van Adelsberg, MD, Thomas Loeys, PhD, Nancy.
Physician needs in health informatics: Just ask the docs
Treatment of chronic autoimmune urticaria with omalizumab
A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine–refractory chronic idiopathic urticaria 
William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P
Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA 
Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S
High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects  William Busse, MD, Sheldon Spector, MD, Karin Rosén,
Multicenter study of emergency department visits for food allergies
Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation  Leif Bjermer, MD  Journal of Allergy.
What are the best outcome measurements for atopic eczema
Cluster analysis and prediction of treatment outcomes for chronic rhinosinusitis  Zachary M. Soler, MD, MSc, J. Madison Hyer, MS, Luke Rudmik, MD, MSc,
The Management of Eosinophilic Esophagitis
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management  Scott H. Sicherer, MD, Hugh A. Sampson, MD  Journal.
Biosimilars and drug development in allergic and immunologic diseases
Nicola A. Hanania, MB BS, MS, Bradley E. Chipps, MD, Noelle M
News Beyond Our Pages Journal of Allergy and Clinical Immunology
A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity  Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,
What is an “eosinophilic phenotype” of asthma?
Anaphylaxis epidemiology in patients with and patients without asthma: A United Kingdom database review  Antonio González-Pérez, BPharm, MS, Zuleika Aponte,
Autophagy: Nobel Prize 2016 and allergy and asthma research
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment
News Beyond Our Pages Journal of Allergy and Clinical Immunology
Geographic variability in childhood asthma prevalence in Chicago
Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L
Cardiovascular and cerebrovascular events among patients receiving omalizumab: Pooled analysis of patient-level data from 25 randomized, double-blind,
Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab  Donald W. MacGlashan,
Bruce G. Bender, PhD, Alex Pedan, PhD, Laleh T. Varasteh, RPh, MSF 
News Beyond Our Pages Journal of Allergy and Clinical Immunology
News Beyond Our Pages Journal of Allergy and Clinical Immunology
The impact of a history of asthma on long-term outcomes of people with newly diagnosed chronic obstructive pulmonary disease: A population study  Tetyana.
George Philip, MD, Carolyn M
Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab  Aidan Long, MD, Abdelkader Rahmaoui, MD, Kenneth.
Pınar Uysal, MD, Esben Eller, MSc, PhD, Charlotte G
Asthma progression: Can we and should we measure it?
The Editors' Choice Journal of Allergy and Clinical Immunology
Managing asthma exacerbations in the emergency department: Summary of the National Asthma Education and Prevention Program Expert Panel Report 3 guidelines.
Macrolide antibiotics and asthma treatment
Budesonide Inhalation Suspension Versus Montelukast in Children Aged 2 to 4 Years with Mild Persistent Asthma  Stanley J. Szefler, MD, Lars-Goran Carlsson,
Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge  Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.
Asthma: The past, future, environment, and costs
Asthma Control Test: Reliability, validity, and responsiveness in patients not previously followed by asthma specialists  Michael Schatz, MD, MS, Christine.
Environmental factors and eosinophilic esophagitis
Paradoxical psoriasis following anti–TNF therapy in ankylosing spondylitis: A population- based cohort study  Jung Min Bae, MD, PhD, Hyuck Sun Kwon, MD,
The prevalence and natural course of food protein–induced enterocolitis syndrome to cow’s milk: A large-scale, prospective population-based study  Yitzhak.
Advances in pediatric asthma in 2007
News Beyond Our Pages Journal of Allergy and Clinical Immunology
Natural history of cow’s milk allergy
The Editors’ Choice Journal of Allergy and Clinical Immunology
News Beyond Our Pages Journal of Allergy and Clinical Immunology
Presentation transcript:

Cardiovascular and cerebrovascular events among patients receiving omalizumab: Results from EXCELS, a prospective cohort study in moderate to severe asthma  Carlos Iribarren, MD, MPH, PhD, Abdelkader Rahmaoui, MD, Aidan A. Long, MD, Stanley J. Szefler, MD, Mary S. Bradley, MS, Gillis Carrigan, PhD, MSc, Mark D. Eisner, MD, MPH, Hubert Chen, MD, MPH, Theodore A. Omachi, MD, MBA, Michael E. Farkouh, MD, MSc, Kenneth J. Rothman, DrPH  Journal of Allergy and Clinical Immunology  Volume 139, Issue 5, Pages 1489-1495.e5 (May 2017) DOI: 10.1016/j.jaci.2016.07.038 Copyright © 2016 The Authors Terms and Conditions

Fig 1 Identification and adjudication of CV and CBV events. MedDRA, Medical Dictionary for Regulatory Activities; SMQ, Standardized Medical Dictionary for Regulatory Activities Query. Journal of Allergy and Clinical Immunology 2017 139, 1489-1495.e5DOI: (10.1016/j.jaci.2016.07.038) Copyright © 2016 The Authors Terms and Conditions

Fig 2 Kaplan-Meier plot of time to first adjudicated study-emergent ATE SAE. Journal of Allergy and Clinical Immunology 2017 139, 1489-1495.e5DOI: (10.1016/j.jaci.2016.07.038) Copyright © 2016 The Authors Terms and Conditions

Fig E1 Patient use of OCSs during EXCELS, by treatment cohort and asthma severity. BL, Baseline. Journal of Allergy and Clinical Immunology 2017 139, 1489-1495.e5DOI: (10.1016/j.jaci.2016.07.038) Copyright © 2016 The Authors Terms and Conditions