Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon,

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Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon, MD, Ju-Hee Seo, MD, Hyung Young Kim, MD, Jinho Yu, MD, PhD, Byoung-Ju Kim, MD, PhD, Hyo-Bin Kim, MD, PhD, So Yeon Lee, MD, PhD, Kyung Won Kim, MD, PhD, Mi-Jin Kang, BS, Yee-Jin Shin, MD, PhD, Soo-Jong Hong, MD, PhD Journal of Allergy and Clinical Immunology Volume 130, Issue 2, Pages 421-426.e5 (August 2012) DOI: 10.1016/j.jaci.2012.04.052 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 aORs and 95% CIs for AR according to parental history of allergic disease and use of antibiotics in infancy (A), mold exposure in infancy (B), moving to a newly built house during infancy (C), and IL13+2044G/A polymorphism and mold exposure during infancy (D). Fig 1, A-C, show the highest ORs for current AR in children with a history of environmental factors and parental allergic diseases. Logistic regression analysis adjusted by age, sex, body mass index, environmental tobacco smoking, parental allergic diseases, and maternal level of education was used in each analysis. Fig 1, D, shows the highest ORs for current AR in children who had a history of mold exposure in infancy and the IL13+2044G/A polymorphism. There was significant additive (P = .0002) and multiplicative (P = .0144) interaction after adjusting for age, sex, body mass index, and parental history of AR. Journal of Allergy and Clinical Immunology 2012 130, 421-426.e5DOI: (10.1016/j.jaci.2012.04.052) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions