Comprehensive Desmosome Mutation Analysis in North Americans With Arrhythmogenic Right Ventricular Dysplasia/CardiomyopathyCLINICAL PERSPECTIVE by A. Dénise den Haan, Boon Yew Tan, Michelle N. Zikusoka, Laura Ibañez Lladó, Rahul Jain, Amy Daly, Crystal Tichnell, Cynthia James, Nuria Amat-Alarcon, Theodore Abraham, Stuart D. Russell, David A. Bluemke, Hugh Calkins, Darshan Dalal, and Daniel P. Judge Circ Genom Precis Med Volume 2(5):428-435 October 20, 2009 Copyright © American Heart Association, Inc. All rights reserved.

Figure 1. Conservation of the mutated amino acid in 4 novel missense mutations. Figure 1. Conservation of the mutated amino acid in 4 novel missense mutations. Amino acids are represented by their standard abbreviations (I for isoleucine, T for threonine, L for leucine). *Indicates site of mutation. Species are shown by their standard nomenclature. A. Dénise den Haan et al. Circ Cardiovasc Genet. 2009;2:428-435 Copyright © American Heart Association, Inc. All rights reserved.

Figure 2. Kaplan–Meier survival analysis demonstrating cumulative VT-free survival in the study population stratified by presence of a desmosome gene mutation and adjusted for gender. Figure 2. Kaplan–Meier survival analysis demonstrating cumulative VT-free survival in the study population stratified by presence of a desmosome gene mutation and adjusted for gender. A. Dénise den Haan et al. Circ Cardiovasc Genet. 2009;2:428-435 Copyright © American Heart Association, Inc. All rights reserved.