NORE1A mRNA level (NORE1A/GAPDH) NORE1B mRNA level (NORE1B/GAPDH)

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NORE1A mRNA level (NORE1A/GAPDH) NORE1B mRNA level (NORE1B/GAPDH) 1.8 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 I II III (N=26) (N=18) (N=36) NORE1A mRNA level (NORE1A/GAPDH) P < 0.05 WD MD PD (N=25) (N=46) (N=9) I II III NORE1B mRNA level (NORE1B/GAPDH) WD MD PD B Percentage of specimens (%) 80 70 60 50 40 30 20 10 NORE1A level Wild type K-Ras Mutant K-Ras Normal Low (N=49) (N=31) 19 11 NORE1B level 34 (N=55) (N=25) 21 16 9