miR-134: A Human Cancer Suppressor?

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miR-134: A Human Cancer Suppressor? Jing-Yu Pan, Feng Zhang, Cheng-Cao Sun, Shu-Jun Li, Guang Li, Feng-Yun Gong, Tao Bo, Jing He, Rui-Xi Hua, Wei-Dong Hu, Zhan- Peng Yuan, Xin Wang, Qi-Qiang He, De-Jia Li Molecular Therapy - Nucleic Acids Volume 6, Pages 140-149 (March 2017) DOI: 10.1016/j.omtn.2016.11.003 Copyright © 2016 The Authors Terms and Conditions

Figure 1 miR-134 Associates with Various Genes Mediating Cancer Cell Proliferation Upregulated-miR-134 inhibits the expression of cyclin D1/cyclin D2/CDK4, KRAS, EGFR, POGLUT1, and STAT5B repressing cell proliferation, while it inhibits the expression of pERK and WWOX but with increasing proliferation. miR-134 increases the expression of p21, resulting in repressing cell proliferation. Blue arrows, suppression; red arrows, indicate promotion. Molecular Therapy - Nucleic Acids 2017 6, 140-149DOI: (10.1016/j.omtn.2016.11.003) Copyright © 2016 The Authors Terms and Conditions

Figure 2 miR-134 Functions in Cancer Invasion and Metastasis KRAS, Nanog mRNA, HNF4α, EGFR, ITGB1, and FOXM1 are all target genes of miR-134, and miR-134 inhibits their functions, which results in repressing cell invasion and metastasis. Molecular Therapy - Nucleic Acids 2017 6, 140-149DOI: (10.1016/j.omtn.2016.11.003) Copyright © 2016 The Authors Terms and Conditions