Development of International Collaboration in Infectious Disease Research Decennium of International Science and Technology Centre Norbert Jousten ISTC Executive Director September, 8, 2004 Vector

History Founded in 1992 by the governments of the EU, Japan, the USA and Russia; operations began in 1994 in Moscow Norway, S. Korea and Canada joined as Funding Parties Headquarters in Moscow with Branch Offices in Armenia, Belarus, Georgia, Kazakstan, Kirgyzstan and Tajikistan In 2003, ISTC underwent a strategic review and major reorganization 9/17/2018

10 Years of Accomplishment PROLIFIC - > 58,000 scientists engaged in Russia/CIS, and > USD 600 Mill. in funding over 10 years of operation through 2000 projects UNIQUE - 37 nations engaged in cooperative technology development, and growing… RESPECTED - Intergovernmental organization with status of diplomatic mission CLEAN - Legal, audited, effective, & transparent mechanism 9/17/2018

Core Objectives Redirect former WMD scientists of Russia/CIS Promote sustainability Reinforce the transition to the market economy 9/17/2018

ISTC Services Main activities Support and Sustainability Activities Science Project Program Partner Program Support and Sustainability Activities Commercialization Support program Competence Building Workshops: EU, Japan, USA Travel Grant Technologies Database Patenting support, etc. 9/17/2018

Main Activity: Projects Science Project Program -Sponsored by EU, USA, JPN, Canada, Korea -Institutions from sponsor regions participate as collaborators Partner Project Program -A Financing Partner to the ISTC covers 100% of the Project expenses -A Partner’s specific technology needs are satisfied By Sept 2004, the ISTC has financed over 2000 projects for $600 million at over 700 CIS institutes 9/17/2018

The Scientists and Their Technologies Inputs of tens of thousands of highly innovative and talented scientists and engineers at hundreds of CIS institutes World-class expertise in a broad range of technical areas 9/17/2018

ISTC Volume in Bio  450 bio projects funded (as of 3Q 2004) $155M funded (as of 3Q 2004) ~9,000 bio-scientists engaged Broad agency support on all sides: Min Atom, Agr, Health, Science, RMA, RAS, RAAS, et al. Sector experiencing most rapid growth 9/17/2018

ISTC Active Bio-Partners US Governmental Partners: U.S. Defense Threat Reduction Agency/CTR US Department of Health & Human Services (DHHS) U.S. Department of Agriculture IPP, BII EU Governmental Partners : DTI Ministry of Defense UK Business Partners: Europe (Bayer AG, Procter and Gamble Company, Medical Insight A/S, ENEA) Japan (Asahi Kasei Corporation) USA ( General Atomics, The IT Group, Inc.) 9/17/2018

Largest Recipients in Bio 7 State Research Center of Virology and Biotechnology VECTOR, 64/92, 35 Mill USD State Research Center for Applied Microbiology Obolensk, 51/72 Research center of Toxicology and Hygenic Regulation of Biopreparations, Serpukhov 26 Institute of Immunological Engineering, Lubuchani 20 Institute of Highly Pure Biopreparations, St-Peterburg 13 Institute of Bioorganic Chemistry, Moscow 12 Research Center of Molecular Diagnostics and Therapy, Moscow 12 Kazakh Scientific Centre for Quarantine and Zoonotic Diseases 11 National Center for Disease Control (Georgia) 8 Institute of Microbiology and Virology (Kazahkstan) 7 Obolensk 9/17/2018

Evolution of Research Directions in Vector Projects 9/17/2018

Some Biotech Project Results 8 BIOCHIPS: Application: MDR-TB, orthopox virus, herpes virus, HCV/B, HIV, STD, biosecurity Microencapsulated Live Measles Vaccine Vector/DELSI/DOS EIMB/Vector/US DHHS 9/17/2018

Some Biotech Project Results 9 9 HIV/AIDS combatting Vivarium & Animal Breeding Facilities Reconstruction Biosecurity Training on Animal Care and Use Compliance to International Standards 9/17/2018

Some Biotech Project Results Biological and Physical Safety Upgrade (DTRA) (Obolensk, Pokrov, Golitsyno, Vector) Main tasks: Biosecurity Installation of CCTV, fire-warning system, access control Renovations to security perimeter Biosafety Centralized technical & biomedical support with highly dangerous pathogens Upgrade electronic communication system 9/17/2018

Communication Support Program Financing the purchase of computer equipment, establishing internet connections, creating internal information systems and websites, journal subscriptions, etc. Institutes: VECTOR, Novosibirsk Research Center for Applied Microbiology, Оbolensk Research Center of Toxicology & Hygienic Regulation of Biopreparations, Serpukhov State Research Center for Epidemiology, Moscow Institute of Engineering Immunology, Lubuchani, Pokrov Plant of Biopreparations, Volginsky 9/17/2018

Seminars and Training A large number of international conferences, symposiums, workshops in CIS institutions and abroad Training in comprehensive high-tech, information technologies, language, business, IPR, GLP, GMP 9/17/2018

Summary We want to be part of your product and technology roadmap in the CIS We provide a broad range of tailored services We’re successful when our Partners and Institutes are successful … Our goal is long-term sustainable ventures with CIS former WMD scientists 9/17/2018

Thank you for your attention! 9/17/2018