Volume 68, Issue 4, Pages 854-855 (April 2018) Rapidly growing, moderately differentiated HCC: A clinicopathological characteristic of HCC occurrence after IFN-free DAA therapy?  Yasuhiko Nakao, Satoru Hashimoto, Seigo Abiru, Atsumasa Komori, Kazumi Yamasaki, Shinya Nagaoka, Akira Saeki, Shigemune Bekki, Yuki Kugiyama, Tamotsu Kuroki, Masahiro Ito, Kazuhiko Nakao, Hiroshi Yatsuhashi  Journal of Hepatology  Volume 68, Issue 4, Pages 854-855 (April 2018) DOI: 10.1016/j.jhep.2017.11.011 Copyright © 2017 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Tumor marker kinetics in six cases. The tumor marker DT was calculated in five cases. DT1, DT2, DT3, DT5 and DT6 are the DTs for cases 1, 2, 3, 5 and 6. The AFP-DT in cases 1, 2, and 3 and the DCP-DT in cases 5 and 6 were calculated as described in a previous study.4 DT1, DT2, DT3 and DT6 were calculated at three-month intervals. DT5 was calculated at six-month intervals. DT1, DT2, DT3, DT5 and DT6 were 26, 31, 15, 27 and 50 days. The numbers in the black boxes show the values of tumor markers at the time of HCC diagnosis. The numbers in the white boxes show tumor marker kinetics before HCC diagnosis. AFP, alpha-fetoprotein; DCP, des-gamma-carboxy prothrombin; DT, doubling time. Journal of Hepatology 2018 68, 854-855DOI: (10.1016/j.jhep.2017.11.011) Copyright © 2017 European Association for the Study of the Liver Terms and Conditions