by Qi Sun, Monik C. Jiménez, Mary K. Townsend, Eric B. Rimm, JoAnn E

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Plasma Levels of Fetuin-A and Risk of Coronary Heart Disease in US Women: The Nurses' Health Study by Qi Sun, Monik C. Jiménez, Mary K. Townsend, Eric B. Rimm, JoAnn E. Manson, Christine M. Albert, and Kathryn M. Rexrode J Am Heart Assoc Volume 3(3):e000939 June 19, 2014 © 2014 Qi Sun et al.

Odds ratio (95% CI) of coronary heart disease for plasma fetuin-A levels by high-sensitivity C-reactive protein concentrations. Odds ratio (95% CI) of coronary heart disease for plasma fetuin-A levels by high-sensitivity C-reactive protein concentrations. Multivariate logistic regression models were adjusted for the same set of covariates for model 3 in Table 3, as well as matching factors. P for interaction=0.04. Qi Sun et al. J Am Heart Assoc 2014;3:e000939 © 2014 Qi Sun et al.

Dose-response relationship between fetuin-A levels and CHD risk stratified by plasma hsCRP levels. Dose-response relationship between fetuin-A levels and CHD risk stratified by plasma hsCRP levels. Study participants with the lowest and highest 1% of fetuin-A were excluded to minimize potential impact of outliers. Multivariate logistic regression models were adjusted for the same set of covariates for model 3 in Table 3, as well as matching factors. Solid lines are ORs and dashed lines are 95% CIs. The horizontal line is the reference line, and the dotted vertical lines are cut-off points for making quintiles. A, hsCRP levels below median (0.20 mg/dL); (B) hsCRP levels above median. CHD indicates coronary heart disease; hsCRP, high-sensitivity C-reactive protein; ORs, odds ratio. Qi Sun et al. J Am Heart Assoc 2014;3:e000939 © 2014 Qi Sun et al.

Odds ratio (95% CI) of coronary heart disease for plasma fetuin-A levels by other inflammatory marker concentrations. Odds ratio (95% CI) of coronary heart disease for plasma fetuin-A levels by other inflammatory marker concentrations. Multivariate logistic regression models were adjusted for the same set of covariates for model 3 in Table 3, as well as matching factors. The Y axis was on log scale. A, interleukin-6 (IL-6), n=387; (B) tumor necrosis factor, receptor 1 (TNF-R1), n=404; (C) tumor necrosis factor, receptor 2 (TNF-R2), n=404. Qi Sun et al. J Am Heart Assoc 2014;3:e000939 © 2014 Qi Sun et al.

Odds ratio (95% CI) of coronary heart disease for plasma fetuin-A levels by diabetes status, hemoglobin A1c levels, or body mass index at baseline. Odds ratio (95% CI) of coronary heart disease for plasma fetuin-A levels by diabetes status, hemoglobin A1c levels, or body mass index at baseline. Multivariate logistic regression models were adjusted for the same set of covariates for model 3 in Table 3, as well as matching factors. The Y axis was on log scale. A, diabetes status at baseline; (B) hemoglobin A1c. (C) body mass index. Qi Sun et al. J Am Heart Assoc 2014;3:e000939 © 2014 Qi Sun et al.

Odds ratio (95% CI) of coronary heart disease for joint categories of plasma fetuin-A levels and estimated glomerular filtration rate. Odds ratio (95% CI) of coronary heart disease for joint categories of plasma fetuin-A levels and estimated glomerular filtration rate. Multivariate logistic regression models were adjusted for the same set of covariates for model 3 in Table 3. The Y axis was on log scale. Qi Sun et al. J Am Heart Assoc 2014;3:e000939 © 2014 Qi Sun et al.