by Rogelio Zamilpa, and Merry L. Lindsey

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Presentation transcript:

by Rogelio Zamilpa, and Merry L. Lindsey AMP Activated Protein Kinase 2 Protection During Hypertension-Induced Hypertrophy by Rogelio Zamilpa, and Merry L. Lindsey Hypertension Volume 52(5):813-815 November 1, 2008 Copyright © American Heart Association, Inc. All rights reserved.

Figure. AMPK is a common denominator in signaling pathways induced by pressure overload. Figure. AMPK is a common denominator in signaling pathways induced by pressure overload. AKT indicates serine/threonine specific protein kinase; ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; AP-1, activator protein-1; CPT, carnitine palmitoyl transferase; eIF4e, eukaryotic initiation factor; 4-EBP1, eIF4e-binding protein 1; eEF2, eukaryotic elongation factor 2; ERK, extracellular signal-regulated kinase; GATA, GATA binding transcription factor; GLUT, glucose transporter; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; NF-κB, nuclear factor κB; NF-AT, nuclear factor of activated T cells; PKC, protein kinase C; PI3K, phosphoinositide-3 kinase; PTEN, phosphatase and tensin homolog; PKA, protein kinase A; S6K, ribosomal protein S6 kinase-1; STAT, signal transducers and activators of transcription protein; TCS, tuberous sclerosis. Rogelio Zamilpa, and Merry L. Lindsey Hypertension. 2008;52:813-815 Copyright © American Heart Association, Inc. All rights reserved.