An Emerging Role of Natriuretic Peptides

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An Emerging Role of Natriuretic Peptides Biff F. Palmer, MD, Deborah J. Clegg, PhD Mayo Clinic Proceedings Volume 90, Issue 12, Pages 1666-1678 (December 2015) DOI: 10.1016/j.mayocp.2015.08.006 Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Effects of natriuretic peptides on renal function and mechanism by which urinary Na+ excretion is increased. ANP = atrial natriuretic peptide; BNP = brain natriuretic peptide; ECF = extracellular fluid volume; GFR = glomerular filtration rate; IMCD = inner medullary collecting duct. Mayo Clinic Proceedings 2015 90, 1666-1678DOI: (10.1016/j.mayocp.2015.08.006) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Mechanisms by which combined angiotensin receptor blockade and neprilysin inhibition may provide clinical benefits in patients with congestive heart failure. In addition to well-recognized cardiovascular functions, increased natriuretic peptides may lead to improvements in metabolic homeostasis in epicardial and perivascular fat depots providing local beneficial effects on myocardial function. AT1 = angiotensin receptor subtype 1. Mayo Clinic Proceedings 2015 90, 1666-1678DOI: (10.1016/j.mayocp.2015.08.006) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 3 The role of natriuretic peptides in shivering and nonshivering thermogenesis with cold exposure (see text for detailed discussion). ADP = adenosine diphosphate; ANP = atrial natriuretic peptide; ATP = adenosine triphosphate; BNP = brain natriuretic peptide; UCP = uncoupling protein. Mayo Clinic Proceedings 2015 90, 1666-1678DOI: (10.1016/j.mayocp.2015.08.006) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions