NCDs and Alzheimer’s 26th International Conference of Alzheimer's Disease International: The Changing Face of Dementia Toronto, Ontario Canada March 27, 2011

The Good News Global Health Community Committed to Action on NCDs.

World Economic Forum 2009 Report “Non-communicable diseases are among the most severe threats to global economic development, more likely to be realized and potentially more detrimental than fiscal crises, natural disasters, or pandemic influenza.”

Rate of Chronic Conditions Men Women 40 30 20 10 Rate per 1,000 Spain <18 18-49 50-64 65-74 75+ Ages Source: NCHS, 1999

NCDs Related to 21st Century Transformational Change “Non-communicable diseases are intricately linked to globalization, urbanization, and demographic and lifestyle transitions — all ubiquitous forces.” - “Global Non-communicable Diseases — Where Worlds Meet,” New England Journal of Medicine

The Good News The Bad News: AD Gap The global health community is committed to NCDs. The Bad News: AD Gap Driven by Political Agendas Missing Key Drivers of Aging and Alzheimer’s Research and Patient Needs Unmet

UN Resolution on NCDs Missed It “Underscoring the need for concerted action and a coordinated response … to adequately address the … challenges posed by non-communicable diseases, in particular the four most prominent non-communicable diseases, namely, cardiovascular diseases, cancers, chronic respiratory diseases and diabetes,…. Decides to convene a high-level meeting of the General Assembly in September 2011, with the participation of Heads of State and Government, on the prevention and control of non-communicable diseases…”

NCD Interest Explodes and Excludes “Four major risk factors that contribute to non-communicable diseases: tobacco use; diets high in fats, salt and sugar; the harmful use of alcohol; and physical inactivity.” – Seoul Declaration on Non-communicable Disease Prevention and Control in the Western Pacific Region, World Health Organization “Six risk factors associated with non-communicable diseases as the leading global risk factors for death: high blood pressure, tobacco use, high blood glucose levels, physical inactivity, overweight or obesity, and high cholesterol levels.” – World Health Organization 2009 “Trends also suggest that the major risk factors for non-communicable diseases — hypertension, high glucose levels, obesity, and inactivity — are on the rise, especially in developing countries.” – New England Journal of Medicine, 2010 “NCDs share the common risk factors of tobacco use, unhealthy diet and physical inactivity.”                              – NCD Alliance

WHO Risk Factors: Potato Chips, Soda and Alcohol Deaths (millions) Percentage of Total High blood pressure 7.5 12.8 Tobacco use 5.1 8.7 High blood glucose level 3.4 5.8 Physical inactivity 3.2 5.5 Overweight and obesity 2.8 4.8 High cholesterol level 2.6 4.5 Unsafe sex 2.4 4.0 Alcohol use 2.3 3.8 Childhood underweight 2.2 Indoor smoke from solid fuels 2.0 3.3

OECD Weighs-In: Tobacco, Environment and Foods Leading Risk Factors, High Income Countries OECD Economics of Prevention, 2011

Media Attention To Cost of NCDs YES, BUT… It is projected that in the next 10 years, China, India, and Britain will lose $558 billion, $237 billion, and $33 billion, respectively, in national income as a result of largely preventable heart disease, strokes, and diabetes. In the United States, cardiovascular disease and diabetes together cost the country $750 billion annually.

NCD Alliance Communicates Globally and to Stakeholders: Not Far Enough

ALZHEIMER’S

Solving the Mystery Wrong Question: Risk Factors vs. Prevalence/Cost Wrong Metric: Death vs. Healthy and Active Aging Wrong Model: Tobacco vs. Polio or HIV/AIDs Wrong Impact: Life-style focus vs. Innovation Wrong Motivation: Political vs. Health/Fiscal Sustainability

A Strong Argument Data and Research: ‘09/’10 ADI Studies Policy Elites: "Alzheimer's Disease is the 21st-Century Fiscal Crisis“ – November 2010 National Alzheimer’s Plans: France to India, Australia to Japan, Korea to Sweden NGOs Represent a Global Voice and MDGs

“Landmark Report Reveals Massive Global Cost Of Alzheimer's: 1% Of Global GDP - And Growing” World Alzheimer Report 2010 revealed worldwide costs of dementia to exceed US$604 billion. The number of people with dementia will double by 2030, and more than triple by 2050. The costs of caring for people with dementia are likely to rise even faster than the prevalence - especially in the developing world. Aligned to most profound socio-economic phenomenon of the 21st century: Aging Populations

Build on the Aging Platform Longevity + Low Fertility + 450MM 400 350 300 250 200 150 100 50 Build on the Aging Platform Longevity + Low Fertility + 450MM Under 65 65-74 75-84 85+ 400 350 300 250 200 150 100 50 Cases per 1,000 Source: National Center for Health Statistics, 1999 Source: National Center for Health Statistics, 1999

Call to Action: ADI Network Has Global Power and Moral Message Highlight the Truth Advocate Lobby Global Leaders Media Data and Analysis Reporting and Editorial Pages UN Secretariat Jamaica Luxembourg WHO On Behalf of Patients and Caregivers Your Governments