Sweetly Expanding Enzymatic Glycodiversification

Slides:



Advertisements
Similar presentations
Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.
Advertisements

Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics Weng Ruh Wong, Allen G. Oliver,
How do emotion and motivation direct executive control? Luiz Pessoa Trends in Cognitive Sciences Volume 13, Issue 4, Pages (April 2009) DOI: /j.tics
Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &
Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages (April 2010) DOI: /j.tics
Biocompatible Quantum Dots for Biological Applications Sandra J. Rosenthal, Jerry C. Chang, Oleg Kovtun, James R. McBride, Ian D. Tomlinson Chemistry &
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Yves Pommier, Elisabetta Leo, HongLiang Zhang, Christophe Marchand Chemistry.
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.
Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria Alban Pereira, Zhengyu Cao, Thomas.
Context-Specific Target Definition in Influenza A Virus Hemagglutinin-Glycan Receptor Interactions Zachary Shriver, Rahul Raman, Karthik Viswanathan, Ram.
Staphylococcus aureus and Bacillus subtilis W23 Make Polyribitol Wall Teichoic Acids Using Different Enzymatic Pathways Stephanie Brown, Timothy Meredith,
Glycosidase Inhibition by Macrolide Antibiotics Elucidated by STD-NMR Spectroscopy Ali Sadeghi-Khomami, Michael D. Lumsden, David L. Jakeman Chemistry.
Nucleosomes and Cisplatin
Volume 22, Issue 5, Pages v-vi (May 2015)
Volume 18, Issue 1, Pages (January 2011)
Now Playing: Farnesol in the Biofilm
Tailor-Made Peptide Synthetases
Nucleosomes and Cisplatin
On-Bead Library Screening Made Easier
Alexander Stein, Reinhard Jahn  Neuron 
Antibiotics: A New Hope
Foundations for Directed Alkaloid Biosynthesis
Ribosome Evolution for Two Artificial Amino Acids in E. coli
Nature’s Strategy for Catalyzing Diels-Alder Reaction
Chemical Proteomics of Host-Pathogen Interaction
Comparative Cognition: Action Imitation Using Episodic Memory
Facilitating the Design of Fluorinated Drugs
Adding Specificity to Artificial Transcription Activators
Finding the Missing Code of RNA Recognition by PUF Proteins
Tuberculosis Terpene Targets
News in Ubiquinone Biosynthesis
Paul B. Whittredge, Justin W. Taraska  Chemistry & Biology 
Nucleic Acid Detection using MNAzymes
JAK3 Specific Kinase Inhibitors: When Specificity Is Not Enough
Activity-Based Profiling of 2-Oxoglutarate Oxygenases
Jeremy J. Minty, S. Marjan Varedi K, Xiaoxia Nina Lin 
Targeting the Undruggable Proteome: The Small Molecules of My Dreams
Optimizing Glycosyltransferase Specificity via “Hot Spot” Saturation Mutagenesis Presents a Catalyst for Novobiocin Glycorandomization  Gavin J. Williams,
Detection of Activated, TIMP-free MMPs
A Noncanonical Path to Mechanism of Action
Redesign of a Dioxygenase in Morphine Biosynthesis
No Need To Be Pure: Mix the Cultures!
Resolving Resolvins Chemistry & Biology
Ins and Outs of Kinase DFG Motifs
Confessions of a journal junkie
Now Playing: Farnesol in the Biofilm
Macrophage Activation: On PAR with LPS
Ribosome Evolution for Two Artificial Amino Acids in E. coli
BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons
Making a New Turn In Matrix Metalloprotease Inhibition
Volume 21, Issue 8, Pages v-vi (August 2014)
Animal Behavior: Timing in the Wild
Ligand Control of G Protein-Coupled Receptor Activity: New Insights
Foundations for Directed Alkaloid Biosynthesis
Volume 15, Issue 3, Pages (March 2008)
Volume 16, Issue 4, Pages (April 2009)
Breaking Down Order to Keep Cells Tidy
Nature’s Strategy for Catalyzing Diels-Alder Reaction
L-DOPA Ropes in tRNAPhe
Harnessing the Antioxidant Power with ARE-Inducing Compounds
Designing Chimeric LOV Photoswitches
Volume 21, Issue 9, Pages (September 2014)
Inflammatory Twins from PI3K Gang Brought to Justice?
Self-Assembling, Dynamic αPNAs
Structure of the EntB Multidomain Nonribosomal Peptide Synthetase and Functional Analysis of Its Interaction with the EntE Adenylation Domain  Eric J.
Tools to Tackle Protein Acetylation
Targeting the Bacterial Z-Ring
Volume 21, Issue 9, Pages (September 2014)
A New Fluorescence-Based Assay for Autophagy
Volume 22, Issue 4, Pages vii-viii (April 2015)
Presentation transcript:

Sweetly Expanding Enzymatic Glycodiversification David L. Jakeman  Chemistry & Biology  Volume 15, Issue 4, Pages 307-308 (April 2008) DOI: 10.1016/j.chembiol.2008.03.009 Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 1 A Crystal Structure of Wild-Type OleD with Bound UDP and Erythromycin The ball-and-stick residues in yellow correspond to the three “hot spots”. The 2° hydroxyl functionality of desosamine is indicated as a dotted sphere. PDB code: 2IYF (Bolam et al., 2007). Figure was generated by PyMol (http://pymol.sourceforge.net). Chemistry & Biology 2008 15, 307-308DOI: (10.1016/j.chembiol.2008.03.009) Copyright © 2008 Elsevier Ltd Terms and Conditions