Attenuation of the “White-Coat Effect” by Antihypertensive Treatment and Regression of Target Organ Damage by Gianfranco Parati, Luisa Ulian, Lorena Sampieri, Paolo Palatini, Alessandra Villani, Alessandro Vanasia, and Giuseppe Mancia Hypertension Volume 35(2):614-620 February 1, 2000 Copyright © American Heart Association, Inc. All rights reserved.

Values for SBP, DBP, and left ventricular mass index (LVMI) obtained at baseline, after 3 and 12 months of antihypertensive treatment, and after the final 1-month placebo period. Values for SBP, DBP, and left ventricular mass index (LVMI) obtained at baseline, after 3 and 12 months of antihypertensive treatment, and after the final 1-month placebo period. Data are shown as means (±SE) for those patients, among the initial 206 included in the SAMPLE Study, whose BP and left ventricular mass index values were available during the various steps of the study. *P<0.01. Gianfranco Parati et al. Hypertension. 2000;35:614-620 Copyright © American Heart Association, Inc. All rights reserved.

Clinic-daytime differences (top) and clinic-home differences (bottom) for SBP and DBP. Data are shown as individual values for the subjects shown in Figure 1. Clinic-daytime differences (top) and clinic-home differences (bottom) for SBP and DBP. Data are shown as individual values for the subjects shown in Figure 1. Differences are separately illustrated for the baseline condition, the 3 (3 mT) and 12 (12 mT) month treatment periods, and the final placebo period. Changes in both clinic-daytime and clinic-home BP differences between baseline and 3 or 12 months of treatment were statistically significant (P<0.01). The corresponding changes between baseline and the final placebo values were significant for only the clinic-daytime BP difference (P<0.05). Gianfranco Parati et al. Hypertension. 2000;35:614-620 Copyright © American Heart Association, Inc. All rights reserved.

Relationship between individual clinic-daytime and clinic-home BP differences for the subjects shown in Figure 1. Relationship between individual clinic-daytime and clinic-home BP differences for the subjects shown in Figure 1. Top, Relationship between baseline values; middle, relationship between treatment-induced changes in clinic-daytime and clinic-home BP differences after 3 months of antihypertensive therapy; bottom, relationship between treatment-induced changes in clinic-daytime and clinic-home BP differences after 12 months of antihypertensive therapy. Data for SBP and DBP are shown separately. T indicates antihypertensive treatment. Gianfranco Parati et al. Hypertension. 2000;35:614-620 Copyright © American Heart Association, Inc. All rights reserved.

Tridimensional plots simultaneously illustrating the relationships between treatment-induced changes in left ventricular mass index (Δ-LVMI), average daytime BP (Δ-BP), and clinic-daytime or clinic-home BP differences (Δ-difference). Tridimensional plots simultaneously illustrating the relationships between treatment-induced changes in left ventricular mass index (Δ-LVMI), average daytime BP (Δ-BP), and clinic-daytime or clinic-home BP differences (Δ-difference). Data are shown separately for SBP (left) and DBP (right) and for clinic-daytime differences (top) and clinic-home differences (bottom). Gianfranco Parati et al. Hypertension. 2000;35:614-620 Copyright © American Heart Association, Inc. All rights reserved.