Arterioscler Thromb Vasc Biol Role of Lipoprotein-Bound NEFAs in Enhancing the Specific Activity of Plasma CETP in the Nephrotic Syndrome by Sylvie Braschi, David Masson, Guy Rostoker, Emmanuel Florentin, Anne Athias, Claude Martin, Bernard Jacotot, Philippe Gambert, Christian Lallemant, and Laurent Lagrost Arterioscler Thromb Vasc Biol Volume 17(11):2559-2567 November 1, 1997 Copyright © American Heart Association, Inc. All rights reserved.

Distribution of NEFAs among plasma lipoprotein fractions. Distribution of NEFAs among plasma lipoprotein fractions. Plasma lipoprotein fractions were isolated by sequential ultracentrifugation and NEFAs were assayed as described in “Methods.” Results are expressed as percentages of total plasma NEFAs bound to each lipoprotein fraction in 15 nephrotic patients and 9 control subjects. Values are mean±SEM. Significance of difference between nephrotic patients and control subjects: **P<.01, Mann-Whitney U test. Sylvie Braschi et al. Arterioscler Thromb Vasc Biol. 1997;17:2559-2567 Copyright © American Heart Association, Inc. All rights reserved.

Effects of supplementation of total plasmas with fatty acid–poor albumin on CETP activity and specific CETP activity. Effects of supplementation of total plasmas with fatty acid–poor albumin on CETP activity and specific CETP activity. CETP activity (upper graphs) is expressed in micrograms of plasma HDL CEs transferred per hour and per milliliter of plasma (see “Methods”). Specific CETP activity (lower graphs) has been calculated as the ratio of the plasma CE transfer activity to the plasma CETP mass concentration and expressed in micrograms of HDL CEs transferred per hour and per milligram of CETP (see “Methods”). CE transfer activities were determined in total plasma that was supplemented or not with fatty acid–poor albumin (40 g/L). Individual decreases in CETP activity and specific CETP activity are represented by thin lines. Mean±SD of nephrotic and control populations are represented by filled circles. Thick lines represent the mean decrease in CE transfer. Probability values were determined by Wilcoxon’s signed rank test. Sylvie Braschi et al. Arterioscler Thromb Vasc Biol. 1997;17:2559-2567 Copyright © American Heart Association, Inc. All rights reserved.