Reduction of FK-506 requirements by combination with polyethylene glycol superoxide dismutase in orthotopic rat liver transplantation Prakash N. Rao,

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Volume 120, Issue 4, Pages (March 2001)

News & Notes Journal of Allergy and Clinical Immunology

Presentation transcript:

Reduction of FK-506 requirements by combination with polyethylene glycol superoxide dismutase in orthotopic rat liver transplantation Prakash N. Rao, PhDa, f, Xin Cai, MDa, f, Raman Venkataramanan, PhDb, Jeffrey L. Platt, MDd, Anthony Demetris, MDa, c, Allen Thunberg, MDe, Connie Faltynek, PhDe, Thomas Starzl, MD, PhDa, Prem Kumar, MDf Journal of Allergy and Clinical Immunology Volume 95, Issue 6, Pages 1276-1281 (June 1995) DOI: 10.1016/S0091-6749(95)70086-2 Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Photomicrograph of rat liver undergoing acute cellular rejection. There is a significant infiltration of inflammatory cells within the portal triads and sinusoids (a). Some tunneling of the infiltrate beneath the portal vein endothelium is also observed (b). (Hematoxylin and eosin; ×64). Journal of Allergy and Clinical Immunology 1995 95, 1276-1281DOI: (10.1016/S0091-6749(95)70086-2) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 2 Photomicrograph of rat liver treated with subthreshold doses of FK-506. Treatment with a suboptimal dose of FK-506 is unable to prevent acute cellular rejection. As in Fig. 1, a significant inflammatory infiltrate is present within the portal triads and sinusoids (a). Some degree of hepatocellular necrosis is also evident (b). (Hematoxylin and eosin; ×64). Journal of Allergy and Clinical Immunology 1995 95, 1276-1281DOI: (10.1016/S0091-6749(95)70086-2) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 3 Photomicrograph of rat liver treated with 30,000 U/kg of PEG-SOD. Treatment with 30,000 U/kg of PEG-SOD alone resulted in a reduction in the cellular infiltration into the sinusoids as compared with Figs. 1 and 2. However, treatment with PEG-SOD alone was unable to completely prevent acute cellular rejection (a). Journal of Allergy and Clinical Immunology 1995 95, 1276-1281DOI: (10.1016/S0091-6749(95)70086-2) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 4 Micrograph of rat liver treated with FK 0.04 mg/kg and 30,000 U/kg of PEG-SOD. Treatment with a combination of PEG-SOD and suboptimal doses of FK-506 results in a significant reduction of cellular infiltration into the portal triads and sinusoids (a). Hepatocellular architecture is better preserved. (Hematoxylin and eosin; × 64). Journal of Allergy and Clinical Immunology 1995 95, 1276-1281DOI: (10.1016/S0091-6749(95)70086-2) Copyright © 1995 Mosby, Inc. Terms and Conditions