Arterioscler Thromb Vasc Biol

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Arterioscler Thromb Vasc Biol Severity of Psoriasis Associates With Aortic Vascular Inflammation Detected by FDG PET/CT and Neutrophil Activation in a Prospective Observational StudySignificance by Haley B. Naik, Balaji Natarajan, Elena Stansky, Mark A. Ahlman, Heather Teague, Taufiq Salahuddin, Qimin Ng, Aditya A. Joshi, Parasuram Krishnamoorthy, Jenny Dave, Shawn M. Rose, Julia Doveikis, Martin P. Playford, Ronald B. Prussick, Alison Ehrlich, Mariana J. Kaplan, Benjamin N. Lockshin, Joel M. Gelfand, and Nehal N. Mehta Arterioscler Thromb Vasc Biol Volume 35(12):2667-2676 November 25, 2015 Copyright © American Heart Association, Inc. All rights reserved.

Flow diagram depicting recruitment scheme for the study. Haley B. Naik et al. Arterioscler Thromb Vasc Biol. 2015;35:2667-2676 Copyright © American Heart Association, Inc. All rights reserved.

Vascular inflammation measured by FDG-PET/CT is associated with psoriasis skin disease severity. Vascular inflammation measured by FDG-PET/CT is associated with psoriasis skin disease severity. A, Tomographic fused positron emission tomography (PET) image of the aortic arch from a patient with severe skin disease and a control patient. B, Regression plots for multivariable regression analysis of vascular inflammation as measured by target-to-background ratio (TBR) with psoriasis area and severity index (PASI) score. CI indicates confidence interval; and FRS, Framingham risk score. Haley B. Naik et al. Arterioscler Thromb Vasc Biol. 2015;35:2667-2676 Copyright © American Heart Association, Inc. All rights reserved.

Proteins involved in innate immunity and neutrophil modulation are higher in plasma from patients with psoriasis versus controls. Proteins involved in innate immunity and neutrophil modulation are higher in plasma from patients with psoriasis versus controls. GM-CSF indicates granulocyte macrophage colony-stimulating factor; IL, interleukin; and TNF, tumor necrosis factor. Haley B. Naik et al. Arterioscler Thromb Vasc Biol. 2015;35:2667-2676 Copyright © American Heart Association, Inc. All rights reserved.

Neutrophil frequencies and mean fluorescence intensities in psoriasis versus control patients. Neutrophil frequencies and mean fluorescence intensities in psoriasis versus control patients. Representative flow cytometry plots (A) and corresponding frequencies of total neutrophils (B) in whole blood. Neutrophils were defined as CD3−CD19−CD15+SSCHi and are presented as percentage of viable cells. C, Mean fluorescence intensity (MFI) of CD62L and CD16 were obtained from the total neutrophil gate. Haley B. Naik et al. Arterioscler Thromb Vasc Biol. 2015;35:2667-2676 Copyright © American Heart Association, Inc. All rights reserved.

Proteins associated with neutrophils are increased in psoriasis. Proteins associated with neutrophils are increased in psoriasis. Neutrophil biomarkers myeloperoxidase (MPO), S100A8/A9, and neutrophil elastase (NE-1) from psoriasis and control patient serum. Haley B. Naik et al. Arterioscler Thromb Vasc Biol. 2015;35:2667-2676 Copyright © American Heart Association, Inc. All rights reserved.

Circulating S100A8/A9 levels are associated with psoriasis severity and vascular inflammation by 18F-fluorodeoxyglucose positron emission tomography computed tomography (FDG PET/CT). Circulating S100A8/A9 levels are associated with psoriasis severity and vascular inflammation by 18F-fluorodeoxyglucose positron emission tomography computed tomography (FDG PET/CT). A, Regression plots for multivariable regression analysis of S100A8/A9 with psoriasis area and severity index (PASI) score for untreated psoriasis patients. B, Regression plots for multivariable regression analysis of S100A8/A9 with vascular inflammation as measured by target-to-background ratio (TBR). CI indicates confidence interval. Haley B. Naik et al. Arterioscler Thromb Vasc Biol. 2015;35:2667-2676 Copyright © American Heart Association, Inc. All rights reserved.