Molecular Diagnostics for Head and Neck Pathology

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Molecular Diagnostics for Head and Neck Pathology Elizabeth Bilodeau, DMD, MD, Faizan Alawi, DDS, Bernard J. Costello, DMD, MD, FACS, Joanne L. Prasad, DDS Oral and Maxillofacial Surgery Clinics Volume 22, Issue 1, Pages 183-194 (February 2010) DOI: 10.1016/j.coms.2009.10.006 Copyright © 2010 Elsevier Inc. Terms and Conditions

Fig. 1 Dual-color FISH illustrating the MAML2 rearrangement. The association between the translocation at t(11;19)(q21;p13) and mucoepidermoid carcinomas has been documented.119 (From Kathleen Cieply, University of Pittsburgh Medical Center; with permission.) Oral and Maxillofacial Surgery Clinics 2010 22, 183-194DOI: (10.1016/j.coms.2009.10.006) Copyright © 2010 Elsevier Inc. Terms and Conditions

Fig. 2 Oral hairy leukoplakia. (A) Hyperkeratosis and intracellular edema of superficial epithelial cells (referred to as “balloon cells”) are seen here (hematoxylin-eosin, original magnification ×10). (B) At a higher power, chromatin beading within nuclei of epithelial cells is seen (hematoxylin-eosin, original magnification ×40). (C) This image demonstrates a negative control for EBER (EBV) by ISH (in situ hybridization, original magnification ×40). (D) This image demonstrates positive cells staining EBER (EBV) by ISH (in situ hybridization, original magnification ×40). Oral and Maxillofacial Surgery Clinics 2010 22, 183-194DOI: (10.1016/j.coms.2009.10.006) Copyright © 2010 Elsevier Inc. Terms and Conditions

Fig. 3 DNA-microarray analysis of Burkitt lymphoma and diffuse large B-cell lymphoma showing differences in gene expression patterns. Colors indicate levels of expression: green indicates genes that are overexpressed in normal cells compared with lymphoma cells; and red indicates genes that are overexpressed in lymphoma cells compared with normal cells. (From Dave SS, Fu K, Wright GW, et al. Molecular diagnosis of Burkitt's lymphoma. N Engl J Med 2006;354:2431–42; with permission. Copyright © 2006 Massachusetts Medical Society.) Oral and Maxillofacial Surgery Clinics 2010 22, 183-194DOI: (10.1016/j.coms.2009.10.006) Copyright © 2010 Elsevier Inc. Terms and Conditions