Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research.

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Presentation transcript:

Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network Loren C. Denlinger, MD, PhD, Christine A. Sorkness, PharmD, Vernon M. Chinchilli, PhD, Robert F. Lemanske, MD Journal of Allergy and Clinical Immunology Volume 119, Issue 1, Pages 3-11 (January 2007) DOI: 10.1016/j.jaci.2006.10.015 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Past and present ACRN and CARE Network clinical trials separated by NAEPP severity steps. The acronyms refer to trials reviewed herein. Escalation of controller therapy selection and dose is appropriate for the moderate and severe strata. Patients who remain symptomatic despite oral corticosteroids and other agents in the severe class should be reevaluated for medication compliance issues, aggressive treatment of other coexisting conditions (eg, vocal cord dysfunction, gastroesophageal reflux, or chronic sinusitis), or both. Journal of Allergy and Clinical Immunology 2007 119, 3-11DOI: (10.1016/j.jaci.2006.10.015) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions