Arterioscler Thromb Vasc Biol Chronic Kidney Disease, Plasma Lipoproteins, and Coronary Artery Calcium Incidence by Julio A. Lamprea-Montealegre, Robyn L. McClelland, Brad C. Astor, Kunihiro Matsushita, Michael Shlipak, Ian H. de Boer, and Moyses Szklo Arterioscler Thromb Vasc Biol Volume 33(3):652-658 February 13, 2013 Copyright © American Heart Association, Inc. All rights reserved.

Kidney function and coronary artery calcium (CAC) incidence probability. Kidney function and coronary artery calcium (CAC) incidence probability. Restricted cubic spline, models with knots at estimated glomerular filtration rate (eGFR) values of 60, 90, and 120 mL/min per 1.73 m2. Model 1 indicates not adjusted for other covariates; Model 2, adjusted for age (continuous), sex, and race; Model 3, adjusted for age (continuous), sex, race, presence of diabetes mellitus (normal, impaired fasting glucose, untreated diabetes mellitus, treated diabetes mellitus), hypertension (normal or hypertension if systolic blood pressure≥140 mm Hg or diastolic blood pressure≥90 mm Hg or use of antihypertensive therapy), and urinary albumin to creatinine ratio. Julio A. Lamprea-Montealegre et al. Arterioscler Thromb Vasc Biol. 2013;33:652-658 Copyright © American Heart Association, Inc. All rights reserved.

Top, Adjusted† standardized concentrations (centered to their mean and standardized to their standard deviations) of nuclear magnetic resonance (NMR) lipoprotein particles stratified by categories of kidney function. Top, Adjusted† standardized concentrations (centered to their mean and standardized to their standard deviations) of nuclear magnetic resonance (NMR) lipoprotein particles stratified by categories of kidney function. Bottom, Adjusted probabilities of high levels of low-density lipoprotein (LDL>130 mg/dL), high levels of triglyceride (TG>150 mg/dL), low levels of high-density lipoprotein (HDL<40 mg/dL), and high levels of non–HDL cholesterol (non–HDL-c) and non–HDL-c/HDL cholesterol (HDL-c; upper quartile: 163 mg/dL and 3.8 for non–HDL-c and non–HDL-c/HDL-c, respectively) across categories of kidney function. * P for trend<0.001. †Adjusted for age (continuous), sex, race, lipid-lowering therapy use, presence of diabetes mellitus (normal, impaired fasting glucose, untreated diabetes mellitus, treated diabetes mellitus), hypertension (normal or hypertension if systolic blood pressure≥140 mm Hg or diastolic blood pressure≥90 mm Hg or use of antihypertensive therapy), and urinary albumin to creatinine ratio. Julio A. Lamprea-Montealegre et al. Arterioscler Thromb Vasc Biol. 2013;33:652-658 Copyright © American Heart Association, Inc. All rights reserved.