Arterioscler Thromb Vasc Biol Monounsaturated and Polyunsaturated n-6 Fatty Acid–Enriched Diets Modify LDL Oxidation and Decrease Human Coronary Smooth Muscle Cell DNA Synthesis by Pedro Mata, Odabella Varela, Rodrigo Alonso, Carlos Lahoz, Manuel de Oya, and Lina Badimon Arterioscler Thromb Vasc Biol Volume 17(10):2088-2095 October 1, 1997 Copyright © American Heart Association, Inc. All rights reserved.

A, Human coronary smooth muscle cell premitotic DNA synthesis induced by serum derived from the subjects during the four dietary periods. A, Human coronary smooth muscle cell premitotic DNA synthesis induced by serum derived from the subjects during the four dietary periods. B, Human coronary SMC premitotic DNA synthesis was significantly higher in female-derived serum than in male-derived serum. DNA synthesis was measured by labeled thymidine incorporation (significance: *versus SFA; + versus MUFA; # versus PUFA n-6; @ male versus female). Pedro Mata et al. Arterioscler Thromb Vasc Biol. 1997;17:2088-2095 Copyright © American Heart Association, Inc. All rights reserved.

Sera derived from postmenopausal women induce significantly higher proliferation than sera derived from premenopausal women. Sera derived from postmenopausal women induce significantly higher proliferation than sera derived from premenopausal women. Axis and significance values as given in Fig 1. Pedro Mata et al. Arterioscler Thromb Vasc Biol. 1997;17:2088-2095 Copyright © American Heart Association, Inc. All rights reserved.