Biogenesis of Nascent High Density Lipoprotein Particles

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Biogenesis of Nascent High Density Lipoprotein Particles Artturi Koivuniemi, Ilpo Vattulainen Structure Volume 23, Issue 7, Pages 1153-1154 (July 2015) DOI: 10.1016/j.str.2015.06.006 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Spherical HDL The work by Segrest et al. (2015) elucidates how nascent HDL is lipidated, the final outcome of the process being largely the HDL particle shown in the figure (diameter ∼8 nm). Shown here is (left) a spherical HDL in full, complemented by (right) a cross-section of the same particle. Color code: ApoA-I proteins (purple for α helices, pink for 310 helices, cyan for turns, and white for coil), phospholipids (blue), cholesterol (green), and cholesterol esters (orange). For simplicity, triglycerides also residing in the hydrophobic core of lipoprotein particles are not accounted for in the model. Visualization by Topi Karilainen/Vattulainen group. Structure 2015 23, 1153-1154DOI: (10.1016/j.str.2015.06.006) Copyright © 2015 Elsevier Ltd Terms and Conditions