Pathogenesis and Treatment of Hepatitis E Virus Infection

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Presentation transcript:

Pathogenesis and Treatment of Hepatitis E Virus Infection Heiner Wedemeyer, Sven Pischke, Michael P. Manns Gastroenterology Volume 142, Issue 6, Pages 1388-1397.e1 (May 2012) DOI: 10.1053/j.gastro.2012.02.014 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 (A) Genomic organization of HEV including the 3 ORFs. The scale shows nucleotides in thousands. (B) Phylogenetic tree depicting different genotypes and subtypes of HEV. The sequences from patients with chronic HEV genotype 3 infection are shown as a separate phylogenetic tree (right). Red squares show chronic HEV patients from Hannover after either heart (HTx) or lung (LTx) transplantation.66 Gastroenterology 2012 142, 1388-1397.e1DOI: (10.1053/j.gastro.2012.02.014) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 (A) Worldwide prevalence of HEV and (B) the geographic distribution of the different HEV genotypes. Gastroenterology 2012 142, 1388-1397.e1DOI: (10.1053/j.gastro.2012.02.014) Copyright © 2012 AGA Institute Terms and Conditions

Figure 3 Diagnosis of hepatitis E. Typical evolution of the serologic titer of HEV-specific antibodies and levels of alanine aminotransferase (ALT) levels during (A) acute self-limited or (B) chronic HEV infection. Gastroenterology 2012 142, 1388-1397.e1DOI: (10.1053/j.gastro.2012.02.014) Copyright © 2012 AGA Institute Terms and Conditions

Figure 4 Course of HEV infection. Gastroenterology 2012 142, 1388-1397.e1DOI: (10.1053/j.gastro.2012.02.014) Copyright © 2012 AGA Institute Terms and Conditions

Supplementary Figure 1 H&E staining of a biopsy sample from a patient with chronic hepatitis E shows portal inflammation with predominant lymphocyte infiltration and interface hepatitis (A, 100×; B, 400×). Gastroenterology 2012 142, 1388-1397.e1DOI: (10.1053/j.gastro.2012.02.014) Copyright © 2012 AGA Institute Terms and Conditions

Gastroenterology 2012 142, 1388-1397. e1DOI: (10. 1053/j. gastro. 2012 Copyright © 2012 AGA Institute Terms and Conditions

Gastroenterology 2012 142, 1388-1397. e1DOI: (10. 1053/j. gastro. 2012 Copyright © 2012 AGA Institute Terms and Conditions

Gastroenterology 2012 142, 1388-1397. e1DOI: (10. 1053/j. gastro. 2012 Copyright © 2012 AGA Institute Terms and Conditions