A. B. C. D E. F. 100 GSK3β pGSK3β pAkt Akt p38/ SAPK

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A. B. C. D. - + - + E. F. 100 GSK3β pGSK3β pAkt Akt p38/ SAPK 0 6 12 24 48 h TSA 80 60 Protein levels (%) 40 pGSK3β 20 pAkt 6 12 24 48 Time (h) C. HDAC1 HDAC2 HDAC3 D. NSC 100 GSK3β pGSK3β pAkt Akt HDAC1 HDAC3 HDAC2 Actin 80 60 GSK3 GSK3β siRNA: Actin NSC Cell survival (%) 40 20 - + - + NSC GSK3β E. F. 0.18 2.6 57.5 17.9 22.0 16.3 34.9 13.8 35.0 2.5 67.8 11.8 34,3 34.0 6.4 23.3 Control TSA GSK3β NSC %<2N %G1 %S %G2/M 0.16 0.14 0.12 Cell survival (OD @ 492 nm) 0.10 0.08 0.06 Control 0.04 0.02 LiCl -8 -9 -5 -6 -7 Log [TSA] M concentration