CYB561 homology modeling. CYB561 homology modeling.A, Close-up of mutation G88R in CYB561. The protein is shown in ribbon presentation in gray, the heme.

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CYB561 homology modeling. CYB561 homology modeling.A, Close-up of mutation G88R in CYB561. The protein is shown in ribbon presentation in gray, the heme ligand is shown in ball-stick presentation and colored cyan. The side chains of the mutant residue, wild-type residue, and the histidine that interacts with the Fe-atom in the heme group are all shown in stick presentation. The wild-type and mutant residues are colored green and red, respectively. B, Overview of the Cyb561 model shown in ribbon presentation. The 2 heme ligands are show in ball-stick presentation and colored cyan. The position of the G88R mutant is indicated in red. Maarten P. van den Berg et al. Circ Res. 2018;122:846-854 Copyright © American Heart Association, Inc. All rights reserved.