Synthesis of Amlodipine

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Presentation transcript:

Synthesis of Amlodipine 2015/06/05 Jun Min Jung

Amlodipine 3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2- chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Total scheme of amlodipine

1

2

3 Knoevenagel condensation

3 Knoevenagel condensation

3 Knoevenagel condensation mechanism

3 Knoevenagel condensation mechanism

3 Knoevenagel condensation mechanism

4 hantzsch dihydropyridine synthesis

hantzsch dihydropyridine synthesis

hantzsch dihydropyridine synthesis

hantzsch dihydropyridine synthesis

hantzsch dihydropyridine synthesis calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure)

5

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