Absolute Quantification of Myocardial Blood Flow Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology Absolute Quantification of Myocardial Blood Flow National Institute of Radiological Sciences Hokkaido University of Graduate School of Medicine Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology BACKGROUND 1-Increasing availability of positron emission tomography myocardial perfusion imaging 2- Absolute quantification of myocardial blood flow (MBF) has become popular in clinical settings 3-Evidences of clinical role of MBF have been developed 4- MBF quantification also have been applied for other imaging including SPECT, CTA, and CMR Copyright American Society of Nuclear Cardiology

METHODS Study type:(Select all that apply) Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology METHODS Study type:(Select all that apply) Prospective/retrospective/randomized/double blind/placebo controlled/observational/case control/cohort. Study subjects: (one sentence summarizing included and/or excluded subjects) Study endpoints: Primary end point(s): Secondary end point(s): Study variables Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology RESULTS Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology RESULTS If figure, insert legend Net extraction by the myocardium as a function of myocardial blood flow with PET flow tracers and other contrast agents. Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology RESULTS Insert a key table or a key figure If figure, insert legend Delete slide if second results slide not necessary Copyright American Society of Nuclear Cardiology

If figure, insert legend Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology RESULTS If figure, insert legend Time-intensity curves of the left ventricular cavity and myocardium. Short-axis MR images at the basal level with the regions of interest (ROIs) set to create the time intensity curves for the left ventricular cavity and whole myocardium. Copyright American Society of Nuclear Cardiology

RESULTS Modality Author Pt No. Diag standard Parameter Se (%) Sp (%) Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology RESULTS Modality Author Pt No. Diag standard Parameter Se (%) Sp (%) 15O-H2O PET Danad et al. 330 90% stenosis FFR<0.8 MFR=2.5 86 72 FFRCT Min 285 FFR<0.8 &CTA 73 90 CT perfusion Kurata 11 ICA stenosis>70% Hyperemic MBF=1.74 88 68 CMR perfusion Biglands 50 Hyperemic MBF=1.60 89.5 80 Copyright American Society of Nuclear Cardiology

Journal of Nuclear Cardiology | Official Journal of the American Society of Nuclear Cardiology CONCLUSIONS 1-Quantitative MBF measurements provide additional diagnostic value over conventional visual imaging 2- Reduced MFR associated with increasing cardiovascular events 3- Dynamic SPECT, CTA, and CMR have great possibilities to evaluate MBF Copyright American Society of Nuclear Cardiology