Latest Advances in HCM.

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Presentation transcript:

Latest Advances in HCM

Program Goals

Disease Burden

Complications and Pathways of Disease Progression

Diagnosis Physical Exam

Diagnosis Family History

Diagnosis ECG

Diagnosis Echocardiogram

Diagnosis Genetic Testing

Diagnosis Challenges

HCM Phenotypes Asymmetric Septal HCM

HCM Phenotypes Apical HCM

Diagnosis CMR Imaging

Symptoms

Obstructive HCM

Obstructive vs Nonobstructive HCM Assessment

Symptomatic Nonobstructive HCM ACCF/AHA Treatment Algorithm

Symptomatic Obstructive HCM ACCF/AHA Treatment Algorithm

Current Pharmacologic Therapies Verapamil

Current Pharmacologic Therapies Disopyramide

Current Pharmacologic Therapies Disopyramide (cont)

Current Pharmacologic Therapies β Blocker

Invasive Therapies ACCF/AHA Recommendations

Investigational Therapies

Ranolazine RHYME

MYK-461 Phase 1 Studies in Healthy Volunteers and Patients With HCM

Eleclazine LIBERTY-HCM

MitraClip™ Percutaneous Mitral Valve Plication

Summary

Abbreviations

Abbreviations (cont)

Abbreviations (cont)