Dengue Eva Archer BIO 402

What is Dengue? http://pakistanweatherportal.com/2011/09/14/punjab-the-dengue-outbreak/ http://www.rcsb.org/pdb/101/motm.do?momID=103

Transmission http://en.citizendium.org/wiki/Dengue_Virus http://www.nature.com/scitable/topicpage/dengue-transmission-22399758

Symptoms Symptoms start 4-7 days after bite and last 3-10 days. To transmit to an uninfected mosquito, the mosquito must feed on a person during a five-day period when there are high amounts of virus in the blood. The virus must then incubate for 8-12 days in the mosquito before it can be transmitted to another human (mosquito is infected for life). high fever, severe headache, severe pain behind the eyes, joint pain, muscle and bone pain, rash, mild bleeding (e.g., nose or gums bleed, easy bruising), low white cell count Dengue Hemorrhagic Fever: after fever begins to decline (2-7 days), capillaries become permeable, allowing fluid to escape into peritoneum and pleural cavity – this can lead to failure of the circulatory system and shock (possibly death) without treatment. http://en.wikipedia.org/wiki/File:Dengue_fever_symptoms.svg

2.5 billion people (40%) in areas with risk of transmission 50-100 million infections yearly 500,000 cases of DHF 22,000 deaths http://www.healthmap.org/dengue/ http://www.healthmap.org/dengue/

Viral Lifecycle Immunopathogenesis of Dengue Virus Infection. J Biomed Sci 2001;8:377–388

Immunopathogenesis of Dengue Virus Infection Immunopathogenesis of Dengue Virus Infection. J Biomed Sci 2001;8:377–388

Genome Organization Immunopathogenesis of Dengue Virus Infection. J Biomed Sci 2001;8:377–388

http://cmr.asm.org/content/22/4/564/F1.expansion.html

Secondary infections and antibody-dependent enhancement