CPIC Update

CPIC: Clinical Pharmacogenetics Implementation Consortium >130 Members Clinicians and scientists 62 institutions 14 countries 12 Observers (NIH and FDA) CPIC Informatics 17 members from 11 organizations 89 in 2013 42 institutions

Published CPIC Guidelines 2011 TPMT – thiopurines Updated March 2013 CYP2C19 – clopidogrel Updated Sept 2013 CYP2C9, VKORC1 – warfarin postponed until after key studies published 2012 CYP2D6 – codeine Updated Feb 2014 HLA-B – abacavir Updated March 2014 SLCO1B1 – simvastatin Updated July 2014 2013 HLA-B – allopurinol Update progress CYP2D6, CYP2C19 - TCAs HLA-B - carbamazepine DPYD - 5FU / capecitabine 2014 IL28B-PEG interferon α CFTR-Ivacaftor G6PD/Rasburicase CYP2C9 and HLA-B/Phenytoin

CPIC Guidelines Status Guidelines Underway Guideline Updates HLA-B/allopurinol: in progress CYP2D6/SSRIs Andrea Gaedigk CYP3A5/tacrolimus Iain MacPhee UGT1A1/atazanavir David Haas CYP2C19/voriconazole Finalizing senior author CYP2D6/ondansetron Guidelines Recently Published CYP2C9 and HLA-B/Phenytoin Tom Callaghan

CPIC guideline genes (n=13) and drugs, September 2014 TPMT MP, TG, azathioprine CYP2D6 Codeine, tramadol, hydrocodone, oxycodone, TCAs CYP2C19 TCAs, clopidogrel, voriconazole VKORC1 warfarin CYP2C9 Warfarin, phenytoin HLA-B Allopurinol, CBZ, abacavir, phenytoin CFTR ivacaftor DPYD 5FU, capecitabine, tegafur G6PD rasburicase SLCO1B1 simvastatin IFNL3 (IL28B) interferon CYP3A5 Tacrolimus UGT1A1 atazanavir

CPIC guideline citations 2011 2012 2013 Black solid line indicates the average citation rates (total citations/total publications) for all publications in fields of Clinical Medicine and Pharmacology & Toxicology for same time period (2014 Journal Citation Reports® Science Edition (Thomson Reuters, 2014))

Guidelines.gov

ASHP and ASCPT are endorsing CPIC guidelines

Purpose: To describe the development process of the CPIC guidelines To compare our process to the Institute of Medicine’s Standards for Developing Trustworthy Clinical Practice Guidelines

Caudle et al, Current Drug Metab 2014

CPIC’s future