I-Flow Corporation Who We Are

Overview Corporate Profile I-Flow History Traditional Pain Management Why treat pain locally? ON-Q* Pain Relief System Why Clinicians Choose the ON-Q* Brand

Who is I-Flow? I-Flow is the exclusive manufacturer and marketer of ON-Q* branded products Offices in Lake Forest, CA Manufacturing in Tijuana, Mexico Started in 1985 Acquired by Kimberly-Clark and became a Kimberly-Clark Health Care Company in November 2009

Corporate Profile >125 Published & Presented Clinical Studies Approx. >80% Market Share ON-Q* pumps have been used in > 3 million surgeries worldwide I-Flow Has Sold a Total of > 40 million Infusion Pumps 170 Field Sales Representatives 80 Clinical Specialists and Nurses 18 Region Business Managers and 4 Zone Directors 18 Regional Anesthesia Training Centers and Cadaver Labs Extensive Speakers Program Dedicated National Accounts Team Dedicated Clinical Research & Education Team International Presence and Distribution National Account Purchasing Affiliation

I-Flow’s Product Evolution Elastomeric technology was applied by physicians for leading edge

Traditional Pain Management Patient Controlled Analgesia (PCA) Epidural Pain Management Oral Opioids Non-opioid Analgesics

Problems Associated with Opioids that May Be Reduced or Eliminated with ON-Q* Pumps+ Nausea and Vomiting Constipation and Ileus Urinary Retention Respiratory Depression Delayed or Restricted Ambulation Sedation Confusion Tolerance/Abuse +Due to a reduction in the use of opioids

Local Anesthetic Pain Pump Market ON-Q* is the global market-leading product for local anesthetic infusion devices. ON-Q* features: Superior pump and catheter technology The greatest variety of pump and catheter combinations to meet the widest variety of clinical needs Superior Value

Superior Value Dedicated sales and clinical team equipped to service account needs Sales, service, support, clinical, patient and reimbursement hotlines PNB Specialists Educational Programs CPNB Educational Centers Ultrasound Courses Speakers Bureau Patient Education Clinical support materials and education Co-op marketing/ Local PR BAXA leasing program Pre-fill program

Why treat pain locally? Systemic Narcotics Epidural Spinal PNB Incisional

ON-Q* FDA Indications Provides significantly better pain relief than narcotics alone Significantly reduces the need for narcotics

ON-Q* Pain Relief System A simple, portable, disposable pain relief system that automatically delivers a local anesthetic to or near a surgery site or near a peripheral nerve over multiple days Provides significantly better pain relief than narcotics alone Significantly reduces the needs for narcotics Elastomeric & Soaker* Catheter Technology Unique, Patented Soaker* Catheter Antimicrobial ON-Q * SilverSoaker* Catheter

ON-Q* Benefits Reduced or eliminated opioid associated side effects and complications, including: Faster, more comfortable recovery Quicker return to normal bowel function, ambulation Reduced risk of post-operative nausea and vomiting (PONV) Reduced length of stay (LOS) Higher patient and family satisfaction

Uses for ON-Q* Pumps Incisional CPNB Used at or near the surgical site area Catheters placed by surgeons Used across multiple specialties, including: CV/CT, General, OB/Gyn, Bariatric, Colo-rectal, Spine, Plastics and Urology. CPNB Used for continuous peripheral nerve blocks (at the peripheral nerves) Catheters placed by regional anesthesiologists Used in orthopedic cases and some abdominal cases (TAP) Ultrasound imaging of the targeted innervation is commonly used.

ON-Q* Pain Relief System Fill port, one-way check valve Pressure source is elastomeric with multi-layer membrane Flow controllers: SELECT-A-FLOW*: Variable Flow Rate ONDEMAND*: PCA Bolus FIXED FLOW RATE: In-line restrictor Filter Clamp Sizes: 100 ml – 600 ml Flow Rates: 0.5 ml/hr – 14 ml/hr

ON-Q* Elastomeric Technology

ON-Q* with SELECT-A-FLOW* (SAF) Controller Developed to meet the demand for variable flow rates Allows titration of flow rate to meet varying clinical needs May help avoid the programming errors associated with electronic pumps

ON-Q* with ONDEMAND* Bolus Allows for continuous infusion plus Patient Controlled Administration (PCA) bolus delivery An extra 5 ml bolus can be administered by the patient as needed every 30 or 60 minutes

ON-Q* Pump with SAF + ONDEMAND 400 ml pump with: SAF ONDEMAND Bolus

More than 125 clinical studies From highly reputable institutions such as: Cleveland Clinic Florida Jewish Hospital Maimonides Medical Center Medical University of South Carolina MD Anderson Cancer Center The University of Texas Southwestern Medical Center at Dallas University of Southern California University of North Carolina, Chapel Hill Washington University, St. Louis Yale University School of Medicine

Why Clinicians Choose ON-Q* Products Wide variety of pump, catheter and accessory options Proven technology with > 3 million surgeries worldwide Significantly better than narcotics alone – non-systemic and avoids side effects of narcotics Significant reduction in narcotic use – less daily consumption and less rescue medication Patients ambulate faster with quicker return of bowel function Reduced length of stay Greater overall patient comfort and patient satisfaction Simple, intuitive and safe to use – no programming, disposable Extensive clinical data, resources and education focus

Questions? Thank you!