Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria Riccardo Asero, MD, Alberto Tedeschi, MD, Raffaella Coppola,

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

“Inflammatory skin march”: IL-1–mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events Keiichi Yamanaka, MD, PhD, Hitoshi.

Clarification concerning amoxicillin skin testing

Fatty acids, inflammation, and asthma

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Atopic dermatitis: Age and race do matter!

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Fatty acids, inflammation, and asthma

Allergic skin diseases

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

The National Biome Initiative: An allergy perspective

Treatment of chronic autoimmune urticaria with omalizumab

A network-based analysis of the late-phase reaction of the skin

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug–related urticaria and angioedema Marek L.

Reply Journal of Allergy and Clinical Immunology

Possible role of TH17 cells in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis Yuichi Teraki, MD, Misaki Kawabe, MD, Seiichi.

Phillip Lieberman, MD, Michael Tankersley, MD

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Phillip Lieberman, MD, David Golden, MD

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Update on the role of prostaglandins in allergic lung inflammation: Separating friends from foes, harder than you might think Martin L. Moore, PhD, R.

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

Sharon Seth, MD, David A. Khan, MD

What is an “eosinophilic phenotype” of asthma?

Weiguo Chen, PhD, Gurjit K. Khurana Hershey, MD, PhD

Cephalosporin Side Chain Cross-reactivity

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Cockroach allergens: Coping with challenging complexity

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Geographic variability in childhood asthma prevalence in Chicago

New pathways for itching in patients with atopic dermatitis?

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Xiu-Min Li, MD, LaVerne Brown, PhD

TH9 immunodeficiency in patients with hyper-IgE syndrome

Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis Eva Gros, MSc, Caroline Bussmann,

Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

Pınar Uysal, MD, Esben Eller, MSc, PhD, Charlotte G

Measles and immunomodulation

Macrolide antibiotics and asthma treatment

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

Asthma: The past, future, environment, and costs

Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticaria Sridharan Soundararajan, PhD, Yoko Kikuchi, DVM, Kusumam Joseph, PhD,

Environmental factors and eosinophilic esophagitis

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,

Advances in pediatric asthma in 2007

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Safety and efficacy of repeated monthly carboplatin desensitization

Immunopathology of atopic dermatitis

Aberrant CARD14 function might cause defective barrier formation

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Itching as a systemic disease

Chitinases and chitinase-like proteins in TH2 inflammation and asthma

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Increased immune reactivity to central nervous system–derived naturally presented peptides in patients with active multiple sclerosis Christine Riedhammer,

Presentation transcript:

Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria Riccardo Asero, MD, Alberto Tedeschi, MD, Raffaella Coppola, PhD, Samantha Griffini, PhD, Paolo Paparella, MD, Piersandro Riboldi, MD, Angelo V. Marzano, MD, Daniele Fanoni, PhD, Massimo Cugno, MD Journal of Allergy and Clinical Immunology Volume 119, Issue 3, Pages 705-710 (March 2007) DOI: 10.1016/j.jaci.2006.08.043 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Plasma prothrombin fragment F1+2 levels in patients and controls. Results are expressed as nmol/L, and horizontal lines represent the mean values. Mean F1+2 plasma levels were significantly higher in patients with CU (P < .001). Journal of Allergy and Clinical Immunology 2007 119, 705-710DOI: (10.1016/j.jaci.2006.08.043) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Plasma D-dimer levels in patients and controls as measured by ELISA. Results are expressed as ng/mL, and horizontal lines represent the mean values. Mean D-dimer plasma levels were significantly higher in patients than in controls (P < .01). Journal of Allergy and Clinical Immunology 2007 119, 705-710DOI: (10.1016/j.jaci.2006.08.043) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Plasma FXIIa levels in patients and controls. Results are expressed as ng/mL, and horizontal lines represent the mean values. No difference in mean values was observed between patients and controls. Journal of Allergy and Clinical Immunology 2007 119, 705-710DOI: (10.1016/j.jaci.2006.08.043) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Plasma FVIIa levels in patients and controls. Results are expressed as ng/mL, and horizontal lines represent the mean values. Mean plasma FVIIa was significantly higher in patients than in controls (P < .001). Journal of Allergy and Clinical Immunology 2007 119, 705-710DOI: (10.1016/j.jaci.2006.08.043) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Scores of tissue factor immunoreactivity in tissue samples from normal skin and urticarial skin lesions. 0, No immunoreactive cells; 1, 1-5 immunoreactive cells; 2, 6-20 immunoreactive cells; 3, >20 immunoreactive cells. Journal of Allergy and Clinical Immunology 2007 119, 705-710DOI: (10.1016/j.jaci.2006.08.043) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 6 Tissue factor immunoreactivity in urticarial skin lesion (A) and normal skin (B) (alkaline phosphatase antialkaline phosphatase method; ×100). Urticaria skin lesions display a strong expression of tissue factor by upper dermal inflammatory cells that is not present in normal skin. In contrast, normal skin appears to be completely negative for tissue factor. Journal of Allergy and Clinical Immunology 2007 119, 705-710DOI: (10.1016/j.jaci.2006.08.043) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions