Cardiopulmonary Interactions in PPHN

Slides:

Advertisements

Similar presentations

VSD Case Discussion. Patient Data 23 y/o female 23 y/o female Underline Disease: Underline Disease: 1. Large VSD 2. Pulmonary hypertension, secondary.

Advertisements

Congenital Diaphragmatic Hernia & Eventration Of Diaphragm

Indications for intervention of ASD and VSD

Hypoxic Respiratory Failure. Disclosures Disclaimer: This activity has been designed to provide continuing education that is focused on specific objectives.

PATENT DUCTUS ARTERIOSUS By: Nicole Stevens. Patent Ductus Arteriosus is a functional connection between the pulmonary artery and the descending aorta.

Meconium Aspiration Syndrome Edited May  PO 2 L --> R ductus arteriosus shunt Ventilation Remove Placenta Ductus Venosus Closes  Systemic Vascular.

Persistent Pulmonary Hypertension (PPHN) F. Hazel R. Villa, MD PL1.

Congenital Heart Defects Functional Overview

By Nicole Stevens. Human fetal circulation works differently to extrauterine circulation, and there are 3 key differences:  The presence of a placenta.

When Oxygen Goes Bad or How Not to Kill a Small Child with O2 Karim Rafaat, MD.

Pulmonary Atresia with Intact Ventricular Septum Ali Sepahdari, MD University of Illinois at Chicago.

Newborn and Early Childhood Respiratory Disorders RT 265 Chapter 33.

1 Mosby items and derived items © 2011, 2006 by Mosby, Inc., an affiliate of Elsevier Inc. Chapter 21 Flail Chest.

Persistent Pulmonary Hypertension of the Newborn (PPHN) Fred Hill, MA, RRT.

CPB & Effects on the Lung Seoul National University Hospital Department of Thoracic & Cardiovascular Surgery.

Respiratory failure Respiratory failure is a pathological process in which the external respiratory dysfunction leads to an abnormal decrease of arterial.

1. Cardiovascular system begins forming at 3 weeks

Definition and Classification of Shock

Picture of my family – love to start talks in the comfort of my living room. Feel passionate about my girls and about this unique population of patients.

Differentiate Pulmonary arterial hypertension from pulmonary venous congestion.

PATHOPHYSIOLOGY OF TRANSPOSITION OF THE ARTERIES (TGA)

RESPIRATORY 221 WEEK 3 PULMONARY BLOOD FLOW. Vascular System  Two Systems : Each have its own reservoir, pump and set of vessels  Pulmonary Circulation.

Cor Pulmonale Dr. Meg-angela Christi Amores. Definition Cor Pulmonale – pulmonary heart disease – dilation and hypertrophy of the right ventricle (RV)

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

PATHOPHYSIOLOGY OF CYANOTIC CHD

Congestive Heart Failure MUHAMMAD ALI PEDIATRIC CARDIOLOGY DIVISION.

Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Obstructive Sleep Apnea and Heart Failure: Pathophysiologic.

Date of download: 7/9/2016 Copyright © The American College of Cardiology. All rights reserved. From: Pulmonary Arterial Hypertension J Am Coll Cardiol.

Ventricular Septal Defect

Pharmacotherapy Of Cardiovascular Disorders: Heart Failure

York Jiao M.D., Lingesh Sivanesan, M.D.

Hemodynamic classification of pulmonary hypertension (PH)

Persistent Pulmonary Hypertension of the Newborn

Copyright © 2017 American Academy of Pediatrics.

Congenital Heart Disease

In diastolic dysfunction, the diastolic pressure-volume relationship is shifted upward and to the left (dashed line), which leads to an elevated left ventricular.

Algorithm for time-sensitive, goal-directed stepwise management of hemodynamic support in newborns. Proceed to next step if shock persists. (1) First hour.

Mei-Yin Lai, Shih-Ming Chu, Satyan Lakshminrusimha, Hung-Chih Lin

Efficacy of Inhalational Nitric Oxide Therapy in the Clinical Management of Persistent Pulmonary Hypertension of the Newborn John P. Kinsella, M.D.,

Heart, Lung and Circulation

(Adapted and reprinted with permission, from Hughes JM et al: Effect of lung volume on the distribution of pulmonary blood flow in man. Respir Physiol.

American College of Cardiology Foundation/American Heart Association 2009 heart failure staging guidelines. CHF, congestive heart failure; CM, cardiomyopathy;

Limitations of right heart catheterization in the diagnosis and risk stratification of patients with pulmonary hypertension related to left heart disease:

RAGE expression was increased in both MCT- and Sugen-injected associated with hypoxia (Sugen) rat experimental PAH models, and RAGE inhibition (siRAGE.

Schematic representation of the relation between lung volume and the pulmonary vascular resistance (PVR). Schematic representation of the relation between.

Management of acute persistent pulmonary hypertension of the newborn (PPHN) (suggested guidelines as recommended by the authors are shown in this figure):

by Victor R. Gordeuk, Oswaldo L. Castro, and Roberto F. Machado

Novel mechanism of mitral regurgitation after lung transplantation in a patient with scleroderma and pulmonary hypertension Christian A. Bermudez, MD,

Lucky Jain, MD, MBA Clinics in Perinatology

Physiological changes in pulmonary arterial hypertension (PAH) patients which occur in response to pregnancy. Physiological changes in pulmonary arterial.

.., - I ':\ ' !' #

A Diagnosis at Hand: Pulmonary Arterial Hypertension

Maternal Antidepressant Use and Risk of PPHN

Pulmonary Hypertension in Congenital Heart Disease

Decompensated right heart failure, intensive care and perioperative management in patients with pulmonary hypertension: Updated recommendations from the.

Definition and Classification of Shock

Etiology and pathophysiology of persistent pulmonary hypertension of the newborn (PPHN). Etiology and pathophysiology of persistent pulmonary hypertension.

Pulmonary Hypertension

Samuel Z. Goldhaber, M.D. Mayo Clinic Proceedings

Echocardiographic evaluation of neonatal hypoxemia based on ductal (black bar) and atrial (blue bar) shunts. Echocardiographic evaluation of neonatal hypoxemia.

Algorithm showing practical approach to persistent pulmonary hypertension of the newborn (PPHN) based on oxygenation, systemic blood pressure, and cardiac.

Reverse remodelling of left and right cavities under specific therapy in a patient with severe idiopathic pulmonary arterial hypertension. a) Before specific.

A) Pressure tracings from the aorta (AO) and pulmonary artery (PA), demonstrating systemic levels of pulmonary arterial pressures. a) Pressure tracings.

Copyright © 2013 Elsevier Inc. All rights reserved.

IntroductionMolecular Structure and Reactivity

Echocardiographic features of persistent pulmonary hypertension of the newborn (PPHN): high right ventricular pressure results in tricuspid regurgitation.

Leah M. Wright et al. JIMG 2016;9:

Schematic drawing of PAH crisis and contributing factors.

Schematic representations of pulmonary hypertension.

(A) The normal cardiovascular circulation.

Presentation transcript:

Cardiopulmonary Interactions in PPHN  PVR SVR  Pulmonary vasculature Heart Structural changes; altered reactivity to dilator and constrictor stimuli RV pressure overload and LV dysfunction Right-to-left shunting at PDA or FO Hypoxia, hypercarbia, acidosis Lung Lung volume  Compliance Intrapulmonary shunt Adapted from J Pediatr, vol. 126, Kinsella JP and Abman SH, Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn, pp. 853-864, Copyright 1995, with permission from Elsevier.