Recombinant Angiotensin-Converting Enzyme 2 Suppresses Pulmonary Vasoconstriction in Acute Hypoxia Axel Kleinsasser, MD, Iris Pircher, MD, Benedict Treml,

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Presentation transcript:

Recombinant Angiotensin-Converting Enzyme 2 Suppresses Pulmonary Vasoconstriction in Acute Hypoxia Axel Kleinsasser, MD, Iris Pircher, MD, Benedict Treml, MD, Martin Schwienbacher, MD, Manfred Schuster, PhD, Eveline Janzek, MD, Hans Loibner, PhD, Josef M. Penninger, MD, Alex Loeckinger, MD Wilderness & Environmental Medicine Volume 23, Issue 1, Pages 24-30 (March 2012) DOI: 10.1016/j.wem.2011.09.002 Copyright © 2012 Wilderness Medical Society Terms and Conditions

Figure 1 The renin-angiotensin system. Angiotensin-converting enzyme 2 (ACE2) reflects both ACE2 and ACE, the classic angiotensin-converting enzyme. Wilderness & Environmental Medicine 2012 23, 24-30DOI: (10.1016/j.wem.2011.09.002) Copyright © 2012 Wilderness Medical Society Terms and Conditions

Figure 2 Multiple inert gas elimination technique parameters. Shunt refers to blood flow to essentially unventilated lung units; AaDO2 is the alveolo-arterial partial pressure difference in mm Hg. Hypoxia or hypoxia and angiotensin-converting enzyme 2 (ACE2) were introduced at time point zero (0). BL, baseline. Wilderness & Environmental Medicine 2012 23, 24-30DOI: (10.1016/j.wem.2011.09.002) Copyright © 2012 Wilderness Medical Society Terms and Conditions

Figure 3 Pulmonary vascular parameters. Hypoxia or hypoxia and angiotensin-converting enzyme 2 (ACE2) were introduced at time point zero (0). *P value <.05; †P value <.01. BL, baseline. Wilderness & Environmental Medicine 2012 23, 24-30DOI: (10.1016/j.wem.2011.09.002) Copyright © 2012 Wilderness Medical Society Terms and Conditions

Figure 4 Angiotensin II plasma concentrations before and after administration of hypoxia or hypoxia and angiotensin-converting enzyme 2. Wilderness & Environmental Medicine 2012 23, 24-30DOI: (10.1016/j.wem.2011.09.002) Copyright © 2012 Wilderness Medical Society Terms and Conditions