Similar Risk of Cardiopulmonary Adverse Events Between Propofol and Traditional Anesthesia for Gastrointestinal Endoscopy: A Systematic Review and Meta-analysis  Vaibhav Wadhwa, Danny Issa, Sushil Garg, Rocio Lopez, Madhusudhan R. Sanaka, John J. Vargo  Clinical Gastroenterology and Hepatology  Volume 15, Issue 2, Pages 194-206 (February 2017) DOI: 10.1016/j.cgh.2016.07.013 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Flow chart showing the process of study selection. Clinical Gastroenterology and Hepatology 2017 15, 194-206DOI: (10.1016/j.cgh.2016.07.013) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 (A) Forest plot showing the OR and 95% CI of each study for developing hypoxia for all procedures combined. The diamond plot indicates the summary OR and 95% CI. (B) Forest plot showing the OR and 95% CI of each study for developing hypotension for all procedures combined. The diamond plot indicates the summary OR and 95% CI. (C) Forest plot showing the OR and 95% CI of each study for developing arrhythmias for all procedures combined. The diamond plot indicates the summary OR and 95% CI. (D) Forest plot showing the OR and 95% CI of each study for developing any complication for all procedures combined. The diamond plot indicates the summary OR and 95% CI. TS, traditional sedatives. Clinical Gastroenterology and Hepatology 2017 15, 194-206DOI: (10.1016/j.cgh.2016.07.013) Copyright © 2017 AGA Institute Terms and Conditions

Figure 3 (A) Forest plot showing the OR and 95% CI of each study for developing hypoxia in NAEG. The diamond plot indicates the summary OR and 95% CI. (B) Forest plot showing the OR and 95% CI of each study for developing hypotension in NAEG. The diamond plot indicates the summary OR and 95% CI. (C) Forest plot showing the OR and 95% CI of each study for developing arrhythmias in NAEG. The diamond plot indicates the summary OR and 95% CI. (D) Forest plot showing the OR and 95% CI of each study for developing any complication in NAEG. The diamond plot indicates the summary OR and 95% CI. TS, traditional sedatives. Clinical Gastroenterology and Hepatology 2017 15, 194-206DOI: (10.1016/j.cgh.2016.07.013) Copyright © 2017 AGA Institute Terms and Conditions

Figure 4 (A) Forest plot showing the OR and 95% CI of each study for developing hypoxia in AEG. The diamond plot indicates the summary OR and 95% CI. (B) Forest plot showing the OR and 95% CI of each study for developing hypotension in AEG. The diamond plot indicates the summary OR and 95% CI. (C) Forest plot showing the OR and 95% CI of each study for developing arrhythmias in AEG. The diamond plot indicates the summary OR and 95% CI. (D) Forest plot showing the OR and 95% CI of each study for developing any complication in AEG. The diamond plot indicates the summary OR and 95% CI. TS, traditional sedatives. Clinical Gastroenterology and Hepatology 2017 15, 194-206DOI: (10.1016/j.cgh.2016.07.013) Copyright © 2017 AGA Institute Terms and Conditions

Figure 5 (A) Funnel plot to detect publication bias for the presence of any complication (hypoxia, hypotension, or arrhythmia). (B) Funnel plot to detect publication bias for the presence of any complication (hypoxia, hypotension, or arrhythmia) for NAEG. EGD, esophagogastroduodenoscopy. Clinical Gastroenterology and Hepatology 2017 15, 194-206DOI: (10.1016/j.cgh.2016.07.013) Copyright © 2017 AGA Institute Terms and Conditions