Cardiovascular and Metabolic Consequences of Testosterone Supplements in Young and Old Male Spontaneously Hypertensive Rats: Implications for Testosterone.

Slides:

Advertisements

Similar presentations

for Bio-Identical Hormones

Advertisements

Effects of Physiologic Testosterone Supplementation on Fat Mass and Distribution in HIV-Infected Men with Abdominal Obesity CM Shikuma, RA Parker, F Sattler,

Blood Pressure. blood pressure is the pressure blood on the walls of the circulatory system. Blood pressure depends on two factors… 1.cardiac output -

Serum Lactate Post-Antibiotic antibiotic † † ＊＊ Kumar et al. J Infect Dis 2006; 193:

Resistant hypertension increases patients’ cardiovascular risk 30% of all treated patients develop resistant hypertension [1-5]. Resistant hypertension.

Hypertension: Specific Aspects in women Najat Joubran Fares M.D St George Hospital University of Balamand.

Ian Graham et al. European Heart Journal 2007;28:

Overweight and Obesity. Overweight People 43.4% of men and 33.7% women in the UK were overweight in 2002, figure is rising Overweight is a body mass index.

5 COMPONENTS OF HEALTH-RELATED FITNESS 1. Muscle endurance 2. Muscle strength 3. Cardiovascular endurance 4. Flexibility 5. Body composition.

Medical Management of obesity Perinatal ANGELS Conference Feb 17, 2005 Philip A. Kern.

Sport Books Publisher1 Weight Management: Finding a Healthy Balance Chapter 11.

David Herne Public Health Specialist Chorley & South Ribble PCT.

The Obesity/Diabetes Epidemic: Adiposopathy & ‘Obesity’- The New Disease! Weight Management in Obesity and DM: Emphasis on New Medical Therapies Stan Schwartz.

FACTORS THAT INCREASE YOUR RISK OF DEVELOPING HIGH BLOOD PRESSURE: Family history of high blood pressure Race (African-Americans are more likely to.

Body Composition. The ratio of fat to lean body tissue.

Headlines How do you feel? Are you bothered?

Nutrition / Fitness Calculation Review. Food Labels 1 gram of fat = _______________ calories/serving 1 gram of protein = _______________ calories/serving.

Cardiovascular Endurance Health 2012 Mr. Vecchio.

The Effects of Growth Hormone and Sex Steroid on Lean Body Mass, Fat Mass, Muscle Strength, Cardiovascular Endurance and Adverse Events in Healthy Elderly.

Volume 58, Issue 6, Pages (December 2000)

Plasma leucine (A), phenylalanine (B) and threonine (C) concentrations following ingestion of either 20 or 40 g of whey protein isolate in both the lower.

Rate of phenylalanine oxidation (A) and plasma urea concentrations (B) following ingestion of either 20 or 40 g of whey protein isolate in both the lower.

Net metabolic rate of walking at 1. 5 m/s vs

Volume 10, Issue 4, Pages (October 2009)

Serum Total 25‐OH Vitamin D Adds Little Prognostic Value in Patients Undergoing Coronary Catheterization by Michael E. Gerling, Matthew T. James, Stephen.

Decrease in Intra-Abdominal Visceral Fat May Reduce Blood Pressure in Obese Hypertensive Women by Hideyuki Kanai, Katsuto Tokunaga, Shigenori Fujioka,

Dyslipidemia and the Risk of Developing Hypertension in a Working‐Age Male Population by Toshiaki Otsuka, Hirotaka Takada, Yasuhiro Nishiyama, Eitaro Kodani,

Prehypertension, Diabetes, and Cardiovascular Disease Risk in a Population-Based Sample by Ying Zhang, Elisa T. Lee, Richard B. Devereux, Jeunliang Yeh,

RAGE expression was increased in both MCT- and Sugen-injected associated with hypoxia (Sugen) rat experimental PAH models, and RAGE inhibition (siRAGE.

Carotid Artery Mechanical Properties of Dahl Salt-Sensitive Rats

Body Mass Index, Sex, and Cardiovascular Disease Risk Factors Among Hispanic/Latino Adults: Hispanic Community Health Study/Study of Latinos by Robert.

Ahead of the Curve by Alun D. Hughes Hypertension Volume 64(5):

Pulse Pressure and Resistance Artery Structure in the Elderly

Prediction of Cardiovascular Disease by the Framingham‐REGICOR Equation in the High‐Risk PREDIMED Cohort: Impact of the Mediterranean Diet Across Different.

Differential Effects of Angiotensin II Type-1 Receptor Antisense Oligonucleotides on Renal Function in Spontaneously Hypertensive Rats by Minoru Yoneda,

Menopause and Hypertension

Postmenopausal Women With Greater Paracardial Fat Have More Coronary Artery Calcification Than Premenopausal Women: The Study of Women's Health Across.

Blood Pressure Rhythmicity and Visceral Fat in Children With HypertensionNovelty and Significance by Anna Niemirska, Mieczysław Litwin, Janusz Feber, and.

MR1-TM inhibits the development of severe ATD and pSS in CD28−/− NOD

Figure 2 Three-year survival rates on the basis of body composition

Table 2. Demographic data from participants

Proportion of Sudden Unexpected Death in North Carolina (SUDDEN) men and women with coronary artery disease (CAD) aged 56–64 years by source of medical.

Type 2 diabetes: Overlap of clinical conditions

Prenatal exposure to nicotine modifies kidney weight and blood pressure in genetically susceptible rats: A case of gene-environment interaction Zdenka.

Exercise and adult women’s health

What do I remember? What is the effect of chronically elevated blood glucose levels on blood vessels? What cardiovascular diseases are a consequence of.

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity Karen K. Ryan, Stephen C. Woods,

Nosratola D. Vaziri, Kaihui Liang, Yaoxian Ding Kidney International

Physiology, Health & Exercise

Dose adjustment of anaesthetics in the morbidly obese

The Hallmarks of BPH Progression and Risk Factors

Volume 58, Issue 6, Pages (December 2000)

Romain Gallet et al. BTS 2016;1:14-28

Entry, Randomization, and Follow-up of Patients in the Hypertension in the Very Elderly Trial Of the 461 patients who did not meet the protocol criteria,

Section II: Lipid management

Chronic effect of 28-day oral administration of vehicle (n = 6–10/group) or aprocitentan 1, 10, and 100 mg/kg per day (n = 6–9/group) on mean arterial.

Effect of 11-day oral administration of vehicle (n = 4) or 6-day oral administration of enalapril 10 mg/kg per day (n = 19), followed by 5-day oral administration.

Internal Medicine Workshop Series Laos September /October 2009

Aldosterone in the development and progression of renal injury

Alterations in cardiorespiratory fitness and body composition following exercise interventions, protein interventions, and combined interventions. Alterations.

(A) Plasma renin activity in Wistar rats, SHRs, and DOCA-salt rats, n = 8 to 9/group; data are presented as mean ± S.E.M. Dose-response relationship on.

Exogenous CRP administration causes fasting hyperglycemia and hyperinsulinemia without altering body composition. Exogenous CRP administration causes fasting.

(A): Five-year mortality in unoperated patients with severe MR with E/E′≥15 was significantly higher compared with patients with E/E′

Effects of Rosi treatment on ASKO mice.

Effects of chow-diet feeding on control and TRIB3 MOE mice.

Mean pulmonary arterial systolic pressure (PASP) with 95% CI error bars and individual data points at rest breathing room air (baseline), during 20 min.

EPA+DHA supplementation does not alter body composition, body weight, or feed intake. EPA+DHA supplementation does not alter body composition, body weight,

Change in mean pulmonary arterial pressure after a 5-min inhalation of the Rho kinase inhibitor Y in rats with hypoxic pulmonary hypertension, with.

Fig. 1. GDF15 is up-regulated with obesity, and AAV-GDF15 improves metabolic parameters in DIO mice. GDF15 is up-regulated with obesity, and AAV-GDF15.

Presentation transcript:

Cardiovascular and Metabolic Consequences of Testosterone Supplements in Young and Old Male Spontaneously Hypertensive Rats: Implications for Testosterone Supplements in Men by Carolina Dalmasso, Chetan N. Patil, Licy L. Yanes Cardozo, Damian G. Romero, and Rodrigo O. Maranon J Am Heart Assoc Volume 6(10):e007074 October 17, 2017 © 2017 Carolina Dalmasso et al.

Serum testosterone and body weight in aging rats. Serum testosterone and body weight in aging rats. A, Endogenous serum testosterone levels decrease with age in male SHR, (n=6/group). *P<0.05 compared with rats aged 3 and 5 mo; #P<0.05, compared with rats, aged 7 to 14 mo; $P<0.05, compared with rats aged 18 mo. B, Body weight increases with aging until 18 mo of age or later (n=6/group). *P<0.05, compared with rats, aged 3 mo; #P<0.05 compared with rats aged 5 mo; $P<0.05, compared with rats, aged 7–12 mo; @P<0.05 vs 14 mo; &P<0.05 vs 18 mo. SHR indicates spontaneously hypertensive rats. Carolina Dalmasso et al. J Am Heart Assoc 2017;6:e007074 © 2017 Carolina Dalmasso et al.

Serum testosterone and body weight in young and old male rats treated with testosterone supplements. Serum testosterone and body weight in young and old male rats treated with testosterone supplements. A, Testosterone supplements increase serum testosterone by 2‐fold in young male SHR (YMSHR‐T), but by 4‐fold in old male SHR (OMSHR‐T). *P<0.05 vs YMSHRP; #P<0.05 vs YMSHR‐T; &P<0.05 vs OMSHR‐P. B, Testosterone supplements decreased body weight in YMSHR‐T but not OMSHR‐T. *P<0.05 vs placebo treated rats. OMSHR‐P indicates old male SHR with placebo; OMSHR‐T, old male SHR with testosterone; SHR, spontaneously hypertensive rats; YMSHR‐P, young male SHR with placebo; YMSHR‐T, young male SHR with testosterone. Carolina Dalmasso et al. J Am Heart Assoc 2017;6:e007074 © 2017 Carolina Dalmasso et al.

Age‐related differences in fat mass and lean mass in young and old males given testosterone supplements. Age‐related differences in fat mass and lean mass in young and old males given testosterone supplements. Testosterone supplements reduced fat mass (A) and lean mass (B) in young male spontaneously hypertensive rats (SHR)—testosterone (YMSHR‐T) compared with controls young male SHR—placebo (YMSHR‐P), but had no effect on either lean mass (C) or fat mass (D) in old male SHR—testosterone (OMSHR‐T). *P<0.05 vs YMSHR‐P. Carolina Dalmasso et al. J Am Heart Assoc 2017;6:e007074 © 2017 Carolina Dalmasso et al.

Plasma estradiol and leptin levels in young and old male SHR with or without testosterone supplements. Plasma estradiol and leptin levels in young and old male SHR with or without testosterone supplements. A, Testosterone supplements increased plasma estradiol in young male SHR (YMSHR) but had no effect in old male SHR (OMSHR). *P<0.05 vs YMSHR‐P (placebo); #P<0.05 vs YMSHR‐T (testosterone). B, Testosterone supplements reduced plasma leptin in YMSHR but had no effect on OMSHR. *P<0.05 vs YMSHR‐P. SHR indicates spontaneously hypertensive rats. Carolina Dalmasso et al. J Am Heart Assoc 2017;6:e007074 © 2017 Carolina Dalmasso et al.

Mean arterial pressure (MAP) in young and old male SHR with and without testosterone supplements. Mean arterial pressure (MAP) in young and old male SHR with and without testosterone supplements. MAP was higher in old male SHR—placebo (OMSHR‐P) than young male SHR—placebo (YMSHR‐P, A). Testosterone supplements increased MAP in young male SHR—testosterone (YMSHR‐T) compared with YMSHR‐P (B), but reduced MAP in old male SHR—testosterone (OMSHR‐T) compared with OMSHR‐P (C). A, *P<0.05 for OMSHR‐P vs YMSHR‐P; B, *P<0.05, OMSHR‐P vs OMSHR‐T; C, *P<0.05, YMSHR‐T vs YMSHR‐P. SHR indicates spontaneously hypertensive rats. Carolina Dalmasso et al. J Am Heart Assoc 2017;6:e007074 © 2017 Carolina Dalmasso et al.

Enalapril reduced mean arterial pressure (MAP) in both young male SHR—placebo (YMSHR‐P) and young male SHR—testosterone (YMSHR‐T), but had a greater effect in YMSHR‐T. *P<0.05, vs YMSHR‐T. Enalapril reduced mean arterial pressure (MAP) in both young male SHR—placebo (YMSHR‐P) and young male SHR—testosterone (YMSHR‐T), but had a greater effect in YMSHR‐T. *P<0.05, vs YMSHR‐T. SHR indicates spontaneously hypertensive rats. Carolina Dalmasso et al. J Am Heart Assoc 2017;6:e007074 © 2017 Carolina Dalmasso et al.