Arterioscler Thromb Vasc Biol Plasma Level of Endogenous Secretory RAGE Is Associated With Components of the Metabolic Syndrome and Atherosclerosis by Hidenori Koyama, Takuhito Shoji, Hisayo Yokoyama, Kohka Motoyama, Katsuhito Mori, Shinya Fukumoto, Masanori Emoto, Tetsuo Shoji, Hironori Tamei, Hirokazu Matsuki, Shigeru Sakurai, Yasuhiko Yamamoto, Hideto Yonekura, Takuo Watanabe, Hiroshi Yamamoto, and Yoshiki Nishizawa Arterioscler Thromb Vasc Biol Volume 25(12):2587-2593 December 1, 2005 Copyright © American Heart Association, Inc. All rights reserved.

Figure 1. Inverse relation between plasma esRAGE levels and carotid or femoral atherosclerosis. Figure 1. Inverse relation between plasma esRAGE levels and carotid or femoral atherosclerosis. Plasma esRAGE level was measured by ELISA. Atherosclerosis was analyzed as intimal-medial thickness (IMT) quantitatively determined by arterial ultrasound. Hidenori Koyama et al. Arterioscler Thromb Vasc Biol. 2005;25:2587-2593 Copyright © American Heart Association, Inc. All rights reserved.

Figure 2. Plasma esRAGE levels were inversely associated with body mass index or HOMA insulin resistance index. Figure 2. Plasma esRAGE levels were inversely associated with body mass index or HOMA insulin resistance index. Plasma esRAGE level was measured by ELISA. Logarithm-transformed HOMA index was used for the analysis for subjects not receiving insulin therapy. Hidenori Koyama et al. Arterioscler Thromb Vasc Biol. 2005;25:2587-2593 Copyright © American Heart Association, Inc. All rights reserved.