Response to cyclosporin and low-dose methylprednisolone in aggressive systemic mastocytosis Motohiro Kurosawa, MD, PhD, PharmDa, Hiroo Amano, MD, PhDb,

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Presentation transcript:

Response to cyclosporin and low-dose methylprednisolone in aggressive systemic mastocytosis Motohiro Kurosawa, MD, PhD, PharmDa, Hiroo Amano, MD, PhDb, Naotomo Kanbe, MD, PhDb, Yasushi Igarashi, MD, PhDb, Hiroshi Nagata, MD, PhDc, Tetsuji Yamashita, BSd, Fumihiko Kurimoto, BSd, Yoshiki Miyachi, MD, PhDe Journal of Allergy and Clinical Immunology Volume 103, Issue 5, Pages S412-S420 (May 1999) DOI: 10.1016/S0091-6749(99)70156-9 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 Changes of the levels of mediators in blood and urine and the eosinophil count during therapy in our patient. Cyclosporin and low-dose methylprednisolone decreased the elevated levels of mediators, and the levels of tryptase and LTC4 fell to within the normal range. ND , Not done. Journal of Allergy and Clinical Immunology 1999 103, S412-S420DOI: (10.1016/S0091-6749(99)70156-9) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 Bone marrow biopsy specimen from our patient with aggressive systemic mastocytosis. Mast cells are stained for tryptase (A ) but not for chymase (B ). Journal of Allergy and Clinical Immunology 1999 103, S412-S420DOI: (10.1016/S0091-6749(99)70156-9) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 3 Biopsy specimens from 2 skin lesions in our patient. Specimens contain mast cells stained for tryptase (A and C ) and chymase (B and D ). Cells containing tryptase, but not chymase, comprise 20% (A and B ) to 50% (C and D ) of the skin mast cells. Journal of Allergy and Clinical Immunology 1999 103, S412-S420DOI: (10.1016/S0091-6749(99)70156-9) Copyright © 1999 Mosby, Inc. Terms and Conditions