Effects of HLA Allele and Killer Immunoglobulin-Like Receptor Ligand Matching on Clinical Outcome in Leukemia Patients Undergoing Transplantation With.

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Effects of HLA Allele and Killer Immunoglobulin-Like Receptor Ligand Matching on Clinical Outcome in Leukemia Patients Undergoing Transplantation With T-cell–Replete Marrow From an Unrelated Donor Yasuo Morishima, Toshio Yabe, Keitaro Matsuo, Koichi Kashiwase, Hidetoshi Inoko, Hiroh Saji, Ken Yamamoto, Etsuko Maruya, Yoshiki Akatsuka, Makoto Onizuka, Hisashi Sakamaki, Hiroshi Sao, Seishi Ogawa, Shunichi Kato, Takeo Juji, Takehiko Sasazuki, Yoshihisa Kodera Biology of Blood and Marrow Transplantation Volume 13, Issue 3, Pages 315-328 (March 2007) DOI: 10.1016/j.bbmt.2006.10.027 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cumulative incidence of relapse and survival by matching of HLA-C in patients with ALL, AML, and CML. All patients were analyzed. The direction of mismatching of HLA-C for relapse is GVH for relapse, and the direction for survival is GVH and/or HVG. The solid line represents match; the dotted line, mismatch. Biology of Blood and Marrow Transplantation 2007 13, 315-328DOI: (10.1016/j.bbmt.2006.10.027) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Cumulative incidence of relapse and survival by matching of HLA-DPB1 in patients with ALL, AML, and CML. All patients were analyzed. The direction of mismatching of HLA-DPB1 for relapse is GVH for relapse, and the direction for survival is GVH and/or HVG. Solid line, match; dotted line, mismatch. Biology of Blood and Marrow Transplantation 2007 13, 315-328DOI: (10.1016/j.bbmt.2006.10.027) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Cumulative incidence of relapse and survival by matching of KIR2DL ligand in the GVH direction in HLA-C–mismatched patients with ALL, AML, and CML. HLA-C–mismatched patients were selected for this analysis. The directions of HLA-C mismatching were GVH and/or HVG. The solid line represents KIR2DL ligand match in the GVH direction; the dotted line, KIR2DL mismatch in the GVH direction. Biology of Blood and Marrow Transplantation 2007 13, 315-328DOI: (10.1016/j.bbmt.2006.10.027) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions