We will begin the MaRISS Coordinator Call shortly… Please place your phone line on mute. 9/19/2018

Overview MaRISS PHA Amendments Pre & Post – Fluctuations Where does MaRISS follow-up data go in PMT PRO Reimbursement We Appreciate YOU! Recruitment update MaRISS Team

PHA Amendments – Extension to 2019 9/19/2018

Study Timeline – EXTENSION from 2017 to 2019 June 2019 subject recruitment ends Sept 2019 site closeout complete 2019 Hospital recruitment ends Subject recruitment continues 2018 Extend hospital contract to 2019 2017 9/19/2018

ACTION ITEM: MaRISS PHA Amendments Extend the study at your site from April 2017 through to 2019 Emails with the agreement amendments have been sent out to all eligible sites Required for each and every active MaRISS hospital, if you have not received this please let us know at mariss@heart.org Work with your legal/regulatory departments to complete this document soon as possible. IMPORTANT CHANGES: IRB reimbursements – please send invoices to mariss@heart.org within 90 days of your IRB approval date. ISC reimbursements – only for 1 person per site ISC 2017 registration receipt/confirmation is required in order for a site to receive reimbursement. Send documentation within 90 days of ISC 2017 to mariss@heart.org 9/19/2018

Pre and Post Hospital Fluctuations 9/19/2018

Pre-Hospital Fluctuations Before patient arrives at your hospital, indicate any documented changes in neurological status – i.e. check EMS/ED records Fluctuations can only be in the opposite direction i.e. from improved to worsening or worsening to improved 9/19/2018

Post-Hospital Fluctuations From arrival at your hospital through to discharge, indicate any documented changes in neurological status – check NIHSSs, discharge notes Fluctuations can only be in the opposite direction i.e. from improved to worsening or worsening to improved 9/19/2018

Entering data in PMT after Follow-up Phone Calls 9/19/2018

Patient Grid 9/19/2018 ©2013, American Heart Association

Click under “Stroke Post Discharge Follow-up” 9/19/2018

If the patient record is “Complete” and MaRISS Follow-up data still needs to be entered: Click on “Create” Save patient record as incomplete, errors will exist for other GWTG Data follow-up elements Quintiles will help to address these specific records that were previously complete and need to be saved as incomplete 9/19/2018 ©2013, American Heart Association

Research Tab: Day 30 Follow-up 9/19/2018 ©2013, American Heart Association

Research Tab: Day 90 Follow-up 9/19/2018 ©2013, American Heart Association

Data Cleaning ACTION ITEM: Initial review of first 500 pts is underway. Please enter data for all current patients. ACTION ITEM: Please enter data into PMT for each MaRISS patient inclusive of day 90 data Reimbursement payments are only made quarterly and only for patients whose day 90 data is completed. 9/19/2018

MaRISS PRO Tool 9/19/2018

Each MaRISS Coordinator should have a HealthCall Account Coordinators should contact HealthCall to request login and Password HealthCall info: 866-944-5433 or support@healthcall.com HealthCall Log in Page: https://secure.healthcall.net/ 9/19/2018

***New*** $50.00 MaRISS PRO Reimbursement As noted in PHA Amendment, for each patient that completes the MaRISS PRO online tool, an additional $50.00 will be paid to the hospital that consented that patient. Applies only to the first 100 patients that complete the PRO tool. 9/19/2018

Steps For Identifying MaRISS PRO Patients Day 1 - Day 3 Consent patient. Collect email address, contact info. Conduct MaRISS assessments. Confirm Day 30, Day 90 process with patient before discharge. **NEW** Day 90 Call During the Day 90 call, assess PRO eligibility for each patient. At the end of the call, ask if you can email them a link to answer the same questions they have completed on the phone. When patient agrees to PRO Log into the PRO tool and enter the patient’s MaRISS ID. Forward the survey link to the patient. Email MaRISS ID to mariss@heart.org Identify PRO Patient in PMT. Reminder: The survey is active for 8 days from the time the patient is entered into the HealthCall web portal. Please remember to remind the patient to complete the survey before it expires. 9/19/2018

We APPRECIATE YOU! Thank you for answering MaRISS Survey on how we can appreciate you. New Promotion: Quarterly Draw for extra ISC registrations – STAY TUNED FOR MORE INFORMATION 9/19/2018

MaRISS Stroke Month Newsletter Stay tuned for Special Edition Stroke Month Newsletter 9/19/2018

MaRISS Recruitment Goals Overall Goal: 2650 Recruits 6 Recruits per Quarter 2 recruits per Month 100 hospitals recruit from May 2015 to 2019 Each hospital recruits 6 patients every 3 months Each hospital recruits 2 patients per month

MaRISS Enrollment Current: 730

Edna Kavuma, Nikesha Riley, Cheyenne Stovall Team update Thank you to Sofie Tai, she is transitioning off our MaRISS team to new role on our Research team MaRISS Team Contacts Edna Kavuma, Nikesha Riley, Cheyenne Stovall Email: mariss@heart.org Phone: 214-706-1994 9/19/2018

Q & A 9/19/2018

Next MaRISS May Coordinator call: TBD stay tuned ROLL CALL Please email mariss@heart.org to let us know you attended this coordinator call. MARK YOUR CALENDARS Next MaRISS May Coordinator call: TBD stay tuned 9/19/2018