Volume 135, Issue 5, Pages (November 2008)

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Volume 135, Issue 5, Pages 1510-1516 (November 2008) Oral Budesonide for Maintenance Treatment of Collagenous Colitis: A Randomized, Double-Blind, Placebo-Controlled Trial Stephan Miehlke, Ahmed Madisch, Birgit Bethke, Andrea Morgner, Eberhard Kuhlisch, Christine Henker, Gerfried Vogel, Matthias Andersen, Eberhard Meier, Gustavo Baretton, Manfred Stolte Gastroenterology Volume 135, Issue 5, Pages 1510-1516 (November 2008) DOI: 10.1053/j.gastro.2008.07.081 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Study design. HRQOL, health-related quality of life. Gastroenterology 2008 135, 1510-1516DOI: (10.1053/j.gastro.2008.07.081) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Flow of patients through the study. *Two budesonide patients in remission declined colonoscopy; therefore, colonoscopies were performed in 15 and 8 patients receiving budesonide and placebo, respectively. Gastroenterology 2008 135, 1510-1516DOI: (10.1053/j.gastro.2008.07.081) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Kaplan–Meier curves of patients with relapse of collagenous colitis during maintenance therapy with oral budesonide 6 mg once daily or placebo. Gastroenterology 2008 135, 1510-1516DOI: (10.1053/j.gastro.2008.07.081) Copyright © 2008 AGA Institute Terms and Conditions

Figure 4 Proportions of patients with clinical remission of collagenous colitis at months 2, 4, and 6 of maintenance therapy with oral budesonide 6 mg once daily or placebo. Gastroenterology 2008 135, 1510-1516DOI: (10.1053/j.gastro.2008.07.081) Copyright © 2008 AGA Institute Terms and Conditions

Figure 5 Mean sIBDQ domain scores at baseline and after 6 weeks of induction therapy with oral budesonide 9 mg once daily in patients with collagenous colitis. Gastroenterology 2008 135, 1510-1516DOI: (10.1053/j.gastro.2008.07.081) Copyright © 2008 AGA Institute Terms and Conditions