Structures of CK1 inhibitors and their effects on CK1 activity in vitro. Structures of CK1 inhibitors and their effects on CK1 activity in vitro. (A) Structures.

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Structures of CK1 inhibitors and their effects on CK1 activity in vitro. Structures of CK1 inhibitors and their effects on CK1 activity in vitro. (A) Structures of D4476 and IC261 (Mashhoon et al, 2000). (B) Purified CK1δ was assayed with phosphorylated peptide TFRPRTSpSNASTIS (30 μM), corresponding to the sequence surrounding residues 312–325 of FOXO1a, at an ATP concentration of 0.1 mM and varying concentrations of D4476 (filled circles), IC261 (open squares) and CKI‐7 (open circles). The results are the average of at least four separate determinations, each performed in duplicate. Graham Rena et al. EMBO Rep. 2004;5:60-65 © as stated in the article, figure or figure legend