Gut-Busters: IL-17 Ain’t Afraid of No IL-23

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Gut-Busters: IL-17 Ain’t Afraid of No IL-23 Natasha Whibley, Sarah L. Gaffen Immunity Volume 43, Issue 4, Pages 620-622 (October 2015) DOI: 10.1016/j.immuni.2015.10.001 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Dichotomy between Anti-IL-23 Antibody Treatment and Anti-IL-17 Treatment in Murine Colitis Blockade of IL-23 ameliorates colitis symptoms in mice, which is associated with reduced expression of inflammatory cytokines and a concomitant increase in the ratio of Treg cells to Th17 cells. Anti-IL-23 therapy is also linked to improvement in epithelial barrier integrity, including increased amounts of Cldn4 mRNA and re-localization of occludin to the tight junction. Conversely, anti-IL-17 or anti-IL-17R antibody treatment triggers elevated amounts of cytokines, decreased Treg cell numbers, epithelial barrier breakdown, and leakiness of lumen contents. Immunity 2015 43, 620-622DOI: (10.1016/j.immuni.2015.10.001) Copyright © 2015 Elsevier Inc. Terms and Conditions