Supplementary Table 1. Dissociation cases of EI and Fibrosis Case 1 2 3 4 5 6 7 8 9 10 Age 59 26 69 54 88 64 67 Sex M F BMI 20.4 31.2 28.4 27.2 21.2 18.4 21.8 24.2 20.3 27.5 Etiology HBV NAFLD HCV AIH HyA 53.3 22.8 51.5 20.9 52.9 1320 226 166 223 67.0 4C7 3.5 5.2 4.2 4.5 9.1 11.0 6.7 6.3 8.7 APRI 0.5 1.8 0.6 0.9 3.4 3.1 0.7 2.3 FIB-4 1.7 0.8 2.3 1.9 4.3 10.9 5.6 3.5 2.4 8.9 EI 3.0 3.8 4.2 4.5 2.6 2.4 Fibrosis F0 F1 F2 F3 F4 Method* Op Bp M, male; F, female; BMI, body mass index; HBV, hepatitis B virus; HCV, hepatitis C virus; AIH, autoimmune hepatitis; NAFLD, non-alcoholic fatty liver disease; HyA, hyaluronic acid; 4C7, type 4 collagen 7S; APRI, aspartate aminotransferase to platelet ratio index; EI, elasticity index; HCC, hepatocellular carcinoma, Op, operation; Bp, liver biopsy. Asterisk means the method to obtain liver histology. Operation had been performed for the treatment of HCC.

Supplementary Table 2. Intraclass correlation coefficient (ICC) in strain elastography Cohort Whole cohort HCV HBV AL/NAFLD n 193 88 41 35 Mean BMI 24.3 24.2 23.8 25.3* ICC 0.835 0.859 0.792 0.703 95% confidential index 0.780-0.875 0.609-0.889 0.785-0.908 0.412-0.850 * Asterisk means statistically significant differences between AL/NAFLD group and other groups. BMI, body mass index; HCV, hepatitis C virus; HBV, hepatitis B virus; AL, alcohol; NAFL, non-alcoholic fatty liver.

Supplementary Fig. 1 BCLC-O, A BCLC-B Cumulative survival rate BCLC-C Survival time (months) Cumulative survival rate BCLC-O, A BCLC-B BCLC-C BCLC-D P<0.001 in log-rank test