Calcification of Medial Elastic Fibers and Aortic Elasticity

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Calcification of Medial Elastic Fibers and Aortic Elasticity by Nathalie Niederhoffer, Isabelle Lartaud-Idjouadiene, Philippe Giummelly, Claude Duvivier, René Peslin, and Jeffrey Atkinson Hypertension Volume 29(4):999-1006 April 1, 1997 Copyright © American Heart Association, Inc. All rights reserved.

Frequency responses of central (•) and peripheral (○) pressure recording systems expressed as variations in amplitude (A, top) and phase lag (phi, bottom). *P<.05 vs A=100% or phi=0° in central pressure recording system; $P<.05 vs A=100% or phi=0° in peripheral pressure recording system; +P<.05 vs peripheral pressure recording system. Frequency responses of central (•) and peripheral (○) pressure recording systems expressed as variations in amplitude (A, top) and phase lag (phi, bottom). *P<.05 vs A=100% or phi=0° in central pressure recording system; $P<.05 vs A=100% or phi=0° in peripheral pressure recording system; +P<.05 vs peripheral pressure recording system. Nathalie Niederhoffer et al. Hypertension. 1997;29:999-1006 Copyright © American Heart Association, Inc. All rights reserved.

Representative example of central aortic pressure signal recorded in unanesthetized, unrestrained control rat showing parameters used to evaluate wave reflections. Representative example of central aortic pressure signal recorded in unanesthetized, unrestrained control rat showing parameters used to evaluate wave reflections. See text for abbreviations. Nathalie Niederhoffer et al. Hypertension. 1997;29:999-1006 Copyright © American Heart Association, Inc. All rights reserved.

Food intake (top), water consumption (middle), and body weight (bottom) during the 2 months after vitamin D3–nicotine treatment (VDN) in control (○) and VDN (•) rats. *P<.05, VDN vs control. Food intake (top), water consumption (middle), and body weight (bottom) during the 2 months after vitamin D3–nicotine treatment (VDN) in control (○) and VDN (•) rats. *P<.05, VDN vs control. Nathalie Niederhoffer et al. Hypertension. 1997;29:999-1006 Copyright © American Heart Association, Inc. All rights reserved.

Linear regression between aortic desmosine plus isodesmosine content (dependent variable) and aortic calcium content (independent variable) within the group of rats treated with vitamin D3 and nicotine (VDN). Linear regression between aortic desmosine plus isodesmosine content (dependent variable) and aortic calcium content (independent variable) within the group of rats treated with vitamin D3 and nicotine (VDN). Nathalie Niederhoffer et al. Hypertension. 1997;29:999-1006 Copyright © American Heart Association, Inc. All rights reserved.

Linear regression between left ventricular mass (dependent variable) and isobaric elasticity (independent variable) within the group of rats treated with vitamin D3 and nicotine (VDN). Linear regression between left ventricular mass (dependent variable) and isobaric elasticity (independent variable) within the group of rats treated with vitamin D3 and nicotine (VDN). Nathalie Niederhoffer et al. Hypertension. 1997;29:999-1006 Copyright © American Heart Association, Inc. All rights reserved.

Normotensive, isobaric pulse wave velocity (top) and pulse amplification (bottom) in awake and phenylephrine-infused pithed control rats (open columns) and rats treated with vitamin D3 and nicotine (VDN) (solid columns). *P<.05, VDN vs control. Normotensive, isobaric pulse wave velocity (top) and pulse amplification (bottom) in awake and phenylephrine-infused pithed control rats (open columns) and rats treated with vitamin D3 and nicotine (VDN) (solid columns). *P<.05, VDN vs control. Nathalie Niederhoffer et al. Hypertension. 1997;29:999-1006 Copyright © American Heart Association, Inc. All rights reserved.

Pulse wave velocity (top) and pulse amplification (bottom) expressed as a function of central aortic mean blood pressure in representative pithed control rats (○) and rats treated with vitamin D3 and nicotine (VDN) (•) after a progressive rise in arterial pressure produced by intravenous infusion of phenylephrine. Pulse wave velocity (top) and pulse amplification (bottom) expressed as a function of central aortic mean blood pressure in representative pithed control rats (○) and rats treated with vitamin D3 and nicotine (VDN) (•) after a progressive rise in arterial pressure produced by intravenous infusion of phenylephrine. Nathalie Niederhoffer et al. Hypertension. 1997;29:999-1006 Copyright © American Heart Association, Inc. All rights reserved.

Linear regression between elastic modulus and isobaric elasticity (dependent variables) and aortic calcium content (independent variable) within the group of rats treated with vitamin D3 and nicotine (VDN). Linear regression between elastic modulus and isobaric elasticity (dependent variables) and aortic calcium content (independent variable) within the group of rats treated with vitamin D3 and nicotine (VDN). Nathalie Niederhoffer et al. Hypertension. 1997;29:999-1006 Copyright © American Heart Association, Inc. All rights reserved.

Linear regression between elastic modulus and isobaric elasticity (dependent variables) and aortic desmosine plus isodesmosine content (independent variable) within the group of rats treated with vitamin D3 and nicotine (VDN). Linear regression between elastic modulus and isobaric elasticity (dependent variables) and aortic desmosine plus isodesmosine content (independent variable) within the group of rats treated with vitamin D3 and nicotine (VDN). Nathalie Niederhoffer et al. Hypertension. 1997;29:999-1006 Copyright © American Heart Association, Inc. All rights reserved.