Neurotransmitters Lec 7.

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Presentation transcript:

Neurotransmitters Lec 7

Norepinephrine (NE) / Locus ceruleus Physiology; NE plays a part in controlling alertness, attention, and memory, it plays important role in causing dreaming (REM sleep). Pathology; Manic-depressive illness (Bipolar disease)

Serotonin / Raphi Neucleus Physiology; Serotonin plays an important role in many behaviors including sleep, appetite, memory, sexual behavior, and mood. Serotonin may play a role in inhibiting transmission of pain in the Spinal Cord. Pathology; when serotonin decreases in brain it causes; Depression , Insomnia.

Reward & Punishment centers

What is addiction? 1. Exposure/feeling of wellbeing 2. Exposure seeking behavior 3. Tolerance 4. Withdrawal 5. dependence

Norepinephrine Serotonin Dopamine Anxiety Irritability Impulse Impulse Impulse mood emotion cognitive function Sex Appetite Aggression Energy Interest Mood, Emotion, Cognitive Function Jour of Psychopharm 11(4 )supp;1997. Pg S27 Motivation Drive Dopamine

Acetylcholine (Ach) Physiology; Ach (Cholinergic) neurons projecting to hippocampus are involved in memory, while projections from nucleus basalis of Meynert, amygdala & the entire neocortex are involved in motivation, perception & cognition. Pathology; In Alzheimer's disease there is extensive Cholinergic loss leading to Dementia.

Hippocampus

Normal vs AD Brain